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Correlation between CHADS
2 and CHA2DS
2-VASc scores and functional outcomes in patients with cryptogenic stroke
Zhang Aidi, Wu Jixia, Si Zheng, Chen Dongxiao
Objective To investigate the correlation between stroke and functional prognosis of patients with cryptogenic stroke (CS) by atrial fibrillation Stroke Risk score (CHADS
2) and atrial fibrillation Stroke risk comprehensive score (CHA2DS2-VASc).
Methods 150 patients with CS who came to our hospital from January 2021 to October 2023 were selected as the study objects.The modified Rankin Scale (mRS) was used to evaluate the prognosis of the patients,and the patients were divided into good prognosis group (
n=82) and poor prognosis group (
n=68).General data and CHADS
2 and CHA2DS
2-VASc scores before admission were compared between the two groups.Receiver operating characteristic (ROC) was used to evaluate the predictive value of CHADS
2 and CHA2DS
2-VASc scores in patients with CS.The risk factors of poor prognosis in CS patients were analyzed by multivariate Logistic regression,and the risk assessment scale was established and verified.Logistic regression model was used to analyze the relationship between CHADS
2 and CHA2DS
2-VASc scores and poor prognosis in CS patients.
Results Compared with patients in the good prognosis group,the proportion of patients with heart failure,stroke history,admission to the National Institute of Health stroke scale (NIHSS) score,serumcreatinine (serumcreatinine,Serumcreatinine) in the poor prognosis group was higher than that in the good prognosis group.Scr),brain natriuretic peptide (BNP),uric acid,CHADS
2 and CHA2DS
2-VASc scores were higher,while left ventricular ejection fraction,LVEF levels were lower (
P<0.05);After adjusting for confounding factors,CHADS
2 and CHA2DS
2-VASc were positively correlated with poor prognosis in CS patients.Subgroup analysis showed that patients with higher CHADS
2 and CHA2DS
2-VASc were more significantly associated with poor prognosis in CS patients (P interaction =0.010,0.008).Multivariate Logistic regression analysis showed that heart failure,stroke history,CHADS
2,CHA2DS2-VASC,NIHSS score on admission,increased BNP level and decreased LVEF level were all risk factors for poor prognosis (
P<0.05).CHADS
2 and CHA2DS
2-VASc scores were effective in predicting poor prognosis in CS patients.And the combination of the two predicted the prognosis was poor and the prediction efficiency was higher.The sensitivity and specificity of 0.5 points were 74.75% and 70.28%,respectively,and the risk of poor prognosis was defined as low risk,2-2.5 as medium risk,and ≥3.5 as high risk.The remaining 100 cases were used to verify the scale.The sensitivity was 79.32 %,the specificity was 78.85 %,the positive predictive value was 70.22 %,and the negative predictive value was 85.64 %.
Conclusion For CS patients,CHADS
2 and CHA2DS
2-VASc scores have predictive value for patients with poor prognosis,and the combination of the two can predict the prognosis of CS patients with higher predictive efficacy.
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