Abstract: Objective To investigate the clinical value of magnetic resonance perfusion weighted imaging (dsc-pwi) combined with neurite directed diffusion and density imaging (noddi) in the grading diagnosis of glioma.Methods 74 patients with glioma treated in our hospital from March 2020 to March 2022 were selected as the observation objects.All patients underwent DSC-PWI and NODDI.To compare the differences of DSC-PWI and NODDI parameters in the focus parenchyma of patients with different grades of glioma.Using pathological examination results as the gold standard,the efficacy of DSC-PWI combined with NODDI and the two alone in diagnosing glioma grade was analyzed.Results RCBV,rCBF and MTT in DSC-PWI parameters of parentologic lesions in low-grade group were (1.35±0.24),(1.35±0.24),(1.02±0.31),respectively.Lower than those in advanced group (4.71±1.03),(4.24±1.21),(1.24±0.32) (P<0.05).The ICVF,ODI and VISO in NODDI parameters of parenchymal lesions in low-grade group were (0.25±0.02),(0.29±0.03),(0.16±0.01) respectively.All of them were lower than those in high grade group (0.39±0.04),(0.35±0.05),(0.22±0.03) (P<0.05).Using pathological examination results as the gold standard,the sensitivity,specificity and accuracy of DSC-PWI combined with NODDI in diagnosing glioma grade were 96.97%,97.56% and 97.30% respectively,which was higher than 75.76%,78.05%,77.03% of DSC-PWI alone and 78.79%,82.93%,81.08% of NODDI alone (all P<0.05).Conclusion DSC-PWI combined with NODDI has a high value in grade diagnosis of glioma.

Key words: Glioma, Hierarchical diagnosis, Magnetic resonance perfusion weighted imaging, Directional diffusion and density imaging of neurite

摘要： 目的 探讨磁共振灌注加权成像(DSC-PWI)联合神经突定向扩散与密度成像(NODDI)技术对脑胶质瘤分级诊断的临床价值。方法 选择我院从2020年3月～2022年3月收治的74例脑胶质瘤患者为观察对象。所有患者均实施DSC-PWI以及NODDI检查,比较不同级别脑胶质瘤患者病灶实质区各项DSC-PWI以及NODDI参数的差异。以病理检查结果为金标准,分析DSC-PWI联合NODDI及两者单独诊断脑胶质瘤分级的效能。结果 低级别组病灶实质区DSC-PWI参数中的rCBV、rCBF及MTT分别为(1.35±0.24)、(1.35±0.24)、(1.02±0.31),均低于高级别组的(4.71±1.03)、(4.24±1.21)、(1.24±0.32)(均P＜0.05)。低级别组病灶实质区NODDI参数中的ICVF、ODI及VISO分别为(0.25±0.02)、(0.29±0.03)、(0.16±0.01),均低于高级别组的(0.39±0.04)、(0.35±0.05)、(0.22±0.03)(均P＜0.05)。以病理检查结果为金标准,DSC-PWI联合NODDI诊断脑胶质瘤分级的灵敏度、特异度以及准确度分别为96.97%、97.56%、97.30%,均高于DSC-PWI单独诊断的75.76%、78.05%、77.03%以及NODDI单独诊断的78.79%、82.93%、81.08%(均P＜0.05)。结论 DSC-PWI联合NODDI对脑胶质瘤分级诊断的价值较高。

关键词: 脑胶质瘤, 分级诊断, 磁共振灌注加权成像, 神经突定向扩散与密度成像