Application of preoperative immune inflammatory index CAR combined with NLR in postoperative prognosis of patients with basal ganglia areahemorrhage

doi:10.19854/j.cnki.1008-2425.2023.04.0008

Abstract

Abstract: Objective To explore the application value of preoperative immune inflammatory index C-reactive protein-Albumin ratio (CAR) combined with Neutrophil-Lymphocyte ratio (NLR) in the prognosis of patients with basal ganglia hemorrhage.Methods The clinical data of 50 patients with basal ganglia hemorrhage who underwent surgical treatment in Jinzhai Chinese Medicine Hospital from January 2020 to December 2022 were retrospectively analyzed,and the data of preoperative blood tests were collected.According to the modified mRSscore of3 months after operation,the patients were divided into two groups:good prognosis group and poor prognosis group.ROC curve and Logistic regression analysis were used to evaluate the predictive value of preoperative CAR combined with NLR in the prognosis of patients.Results The expression levels of preoperative CAR and NLR in patients with poor prognosis were significantly higher than those in patients with good prognosis (P=0.000,P=0.027).Logistic regression analysis showed that preoperative CAR,NLR and GCS scores were independent risk factors for prognosis (P=0.010,P=0.032,P=0.028).ROC curve analysis shows that the optimal cutoff values of preoperative CAR and NLR are 2.52 and 2.71.And the AUC,sensitivity and specificity of the combined prediction of adverse prognosis are better than those of the single application.Conclusion The preoperative immune inflammatory index CAR combined with NLR has important clinical application value in predicting the prognosis of patients with basal ganglia hemorrhage.

Key words: CAR, NLR, Basal ganglia area hemorrhage, Postoperative, Prognosis

摘要： 目的探讨术前免疫炎症指标C反应蛋白-白蛋白比(C-reactive protein-Albuminratio,CAR)联合中性粒细胞-淋巴细胞比(Neutrophil-Lymphocyte ratio,NLR)在基底节区出血手术患者预后中的应用价值。方法回顾性分析2020年1月至2022年12月在金寨县中医院行手术治疗的50例基底节区出血患者的临床资料,收集患者术前血液检验数据。根据术后3个月的改良mRS评分将患者分为预后良好组和预后不良组,利用ROC曲线和Logistic回归分析评估术前CAR联合NLR在患者预后中的预测价值。结果术前CAR和NLR在预后不良组中的表达水平明显高于预后良好组(P=0.000,P=0.027)。Logistic回归分析显示术前CAR、NLR和GCS评分均为影响预后的独立危险因素(P=0.010,P=0.032,P=0.028)。ROC曲线分析显示术前CAR和NLR的最佳分界值分别为2.52和2.71,且二者联合预测不良预后的AUC、敏感度和特异度均优于各自单独应用时。结论术前免疫炎症指标CAR联合NLR,在基底节区出血手术患者预后中具有重要的临床应用价值。

关键词: CAR, NLR, 基底节区出血, 术后, 预后

CLC Number:

R743.34

Chen Shengdian, Xu Shu, Feng Xinglong, et al. Application of preoperative immune inflammatory index CAR combined with NLR in postoperative prognosis of patients with basal ganglia areahemorrhage[J]. Chinese Journal of Stereotactic and Functional Neurosurgery, 2023, 36(4): 233-236.

陈圣典, 许恕, 冯兴隆, 陈义维, 侯仕强. 术前免疫炎症指标CAR联合NLR在基底节区出血手术患者预后中的应用研究[J]. 立体定向和功能性神经外科杂志, 2023, 36(4): 233-236.

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