The relationship between preoperative serum miR-22-3p and miR-4297 with clinical features and postoperative recurrence in patients with glioma

doi:10.19854/j.cnki.1008-2425.2026.01.0004

Abstract

Abstract: Objective To investigate the relationship between preoperative serum levels of microRNA-22-3p (miR-22-3p) and microRNA-4297 (miR-4297) and clinical features,pathological characteristics,and postoperative recurrence in patients with glioma. Methods From January 2021 to January 2024,194 patients with glioma were included as the study subjects.According to whether the original lesion location recurred one year after surgery,they were assigned into a recurrence group of 92 cases and a non recurrence group of 102 cases.Real-time quantitative fluorescence PCR (qPCR) was used to detect serum miR-22-3p and miR-4297 in patients with glioma.Multivariate logistic regression was used to explore the influencing factors of postoperative recurrence in patients with glioma.Receiver operating characteristic (ROC) curves were plotted to explore the predictive value of serum miR-22-3p and miR-4297 for postoperative recurrence in glioma patients. Results Compared with the non-recurrence group,patients in the recurrence group had significantly lower serum levels of miR-22-3p and miR-4297 (P＜0.05).Multivariate logistic regression analysis showed that clinical features such as extent of resection and postoperative radiochemotherapy,pathological features such as tumor diameter,pathological grade,differentiation degree,invasion and infiltration,and serum levels of miR-22-3p and miR-4297 were independent factors affecting postoperative recurrence in glioma patients (P＜0.05).The ROC curve analysis indicated that the combined prediction of postoperative recurrence using serum miR-22-3p and miR-4297 had an area under the curve (AUC) of 0.893,which was significantly higher than individual predictions (miR-22-3p:Z=3.051,P=0.002; miR-4297:Z=2.157,P=0.031). Conclusion Serum miR-22-3p and miR-4297 in glioma patients with postoperative recurrence are reduced and correlated with clinical pathological features.The union of the two has a higher predictive effect on postoperative recurrence.

Key words: Glioma, Clinical features, Recurrence, Microribonucleic acid-22-3p, Microribonucleic acid-4297

摘要： 目的探究脑胶质瘤患者术前血清微小核糖核酸-22-3p(miR-22-3p)、微小核糖核酸-4297(miR-4297)水平与临床特征、病理特征及术后复发的关系。方法选取2021年1月到2024年1月共194例脑胶质瘤患者为研究对象,根据术后一年原病灶位置是否复发分为复发组92例和非复发组102例。实时定量荧光PCR(qPCR)法检测脑胶质瘤患者血清miR-22-3p、miR-4297表达水平;多因素Logistic分析脑胶质瘤患者术后复发影响因素;绘制受试者工作特征(ROC)曲线分析血清miR-22-3p、miR-4297水平对脑胶质瘤患者术后复发有预测价值。结果与非复发组脑胶质瘤患者相比,复发组患者血清miR-22-3p和miR-4297水平显著下降(P＜0.05);多因素Logistic回归分析显示临床特征如切除范围和术后放化疗,病理特征如肿瘤直径、病理级别、分化程度、侵袭浸润和血清miR-22-3p、miR-4297水平均为脑胶质瘤术后复发的独立影响因素(P＜0.05);ROC曲线分析表明血清miR-22-3p和miR-4297联合预测脑胶质瘤术后复发的曲线下面积(AUC)值为0.893,显著高于单独预测(miR-22-3p:Z=3.051,P=0.002;miR-4297:Z=2.157,P=0.031) 结论脑胶质瘤术后复发患者血清miR-22-3p、miR-4297水平降低,与临床病理特征相关,两者联合对术后复发预测效能较高。

关键词: 脑胶质瘤, 临床特征, 复发, 微小核糖核酸-22-3p, 微小核糖核酸-4297

CLC Number:

R739.41

Feng Zhanjiang, Zhang Jun, Jia Haibo, Duan Xiaowei, Han Xiaozheng, Zhang Lei, Li Yifan. The relationship between preoperative serum miR-22-3p and miR-4297 with clinical features and postoperative recurrence in patients with glioma[J]. Chinese Journal of Stereotactic and Functional Neurosurgery, 2026, 39(1): 22-28.

冯占江, 张钧, 贾海波, 段晓伟, 韩晓正, 张磊, 李一凡. 脑胶质瘤患者术前血清miR-22-3p、miR-4297水平与临床特征及术后复发的关系[J]. 立体定向和功能性神经外科杂志, 2026, 39(1): 22-28.

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