Abstract: Objective To investigate the interaction of MRI parameters volume transport constant (Ktrans) and rate constant (Ve) with serum interleukin 10 (IL-10) and vascular endothelial growth factor (VEGF) in patients with glioma and their diagnostic value in the grading of glioma. Methods A retrospective study was conducted,120 patients with brain glioma who were treated in neurosurgery of our hospital from October 2020 to October 2022 were selected as the study group,and another 90 patients who underwent craniotomy due to cerebral hemorrhage were selected as the control group.The study group used dynamic contrast-enhanced MRI to obtain the Ktrans value and Ve value,and compared the levels of serum IL-10 and VEGF between the two groups.Pearson correlation analysis showed the correlation between Ktrans value and Ve value and serum IL-10 and VEGF levels,respectively.The Ktrans and Ve values,serum IL-10 and VEGF levels of patients with different grades of glioma were analyzed,and the diagnostic value of each index on the grade of glioma was analyzed by ROC curve. Results The levels of serum IL-10(25.97±7.41 pg/ml 比 14.79±3.37 pg/ml) and VEGF(167.01±34.32 pg/ml vs 90.86±13.64 pg/ml) in the study group were significantly higher than those in the control group (P＜0.05).There were 63 patients with high grade and 57 patients with low grade,and the levels of serum IL-10(30.62±6.22 pg/ml vs 20.97±4.93 pg/ml),VEGF(191.05±28.61 pg/ml vs 141.22±16.63 pg/ml),Ktrans(0.333±0.097 min^-1 vs 0.234±0.068 min^-1) and Ve(0.473±0.136 min^-1 vs 0.277±0.091 min^-1) in high grade patients were significantly higher than those in low grade patients (P＜0.05).Pearson correlation analysis showed that the grade of glioma was positively correlated with the levels of IL-10,VEGF,Ktrans and Ve (r=0.538,0.624,0.502,0.541;P＜0.001),and the serum levels of IL-10,VEGF were positively correlated with Ktrans and Ve (r=0.552,0.695,0.550,0.602;P＜0.05).The AUC of serum IL-10,VEGF,KTrans and Ve values in diagnosis of high-grade tumors were 0.804 (0.704~0.905),0.808 (0.717~0.900),0.793 (0.701~0.886),0.815 (0.721~0.909),0.882 (0.810~0.953),respectively.The AUC of combined diagnosis was higher than that of single diagnosis (P＜0.05). Conclusion The MRI parameters Ktrans and Ve are positively correlated with the serum levels of IL-10 and VEGF in patients with glioma,and have good diagnostic efficacy for the grading of glioma.

Key words: Brain glioma, Tumor grade, MRI parameters, Interleukin-10, Vascular endothelial growth factor

摘要： 目的 探讨胶质瘤患者MRI参数容积转运常数(Ktrans)和速率常数(Ve)与血清白细胞介素-10(IL-10)、血管内皮生长因子( VEGF)的交互作用及对脑胶质瘤分级的诊断价值。方法 回顾性研究选取2020年10月至2022年10月于我院神经外科接受治疗的120例脑胶质瘤患者为研究组,另选取90例因脑出血而接受开颅手术的患者为对照组。研究组采用MRI动态对比增强扫描获取Ktrans值和Ve值,比较两组患者血清IL-10、VEGF水平。Pearson相关分析Ktrans值和Ve值分别与血清IL-10、VEGF水平的相关性。分析不同脑胶质瘤分级患者Ktrans值和Ve值与血清IL-10、VEGF水平,以及采用ROC曲线分析各指标对脑胶质瘤分级的诊断价值。结果 研究组血清IL-10(25.97±7.41 pg/ml 比 14.79±3.37 pg/ml)、VEGF(167.01±34.32 pg/ml 比 90.86±13.64 pg/ml)水平明显高于对照组,差异有统计学意义(P＜0.05)。高级别、低级别患者分别63例、57例,其中高级别患者血清IL-10(30.62±6.22 pg/ml 比 20.97±4.93 pg/ml)、VEGF(191.05±28.61 pg/ml 比 141.22±16.63 pg/ml)水平以及Ktrans值(0.333±0.097 min^-1 比 0.234±0.068 min^-1)和Ve值(0.473±0.136 min^-1 比 0.277±0.091 min^-1)均明显高于低级别患者(P＜0.05)。Pearson相关分析显示,胶质瘤分级与IL-10、VEGF水平以及Ktrans值和Ve值值呈正相关性(r=0.538,0.624,0.502,0.541;P＜0.001),胶质瘤患者血清IL-10、VEGF水平分别与Ktrans值和Ve值呈正相关性(r值分别为0.552、0.695、0.550、0.602;P＜0.05)。血清IL-10、VEGF、Ktrans值和Ve值诊断高级别肿瘤的AUC分别为0.804(0.704~0.905)、0.808(0.717~0.900)、0.793(0.701~0.886)、0.815(0.721~0.909)、0.882(0.810~0.953),其中联合诊断的AUC高于单独诊断(P＜0.05)。结论 胶质瘤患者MRI参数Ktrans值和Ve值与血清IL-10、VEGF水平呈正相关性,且对于脑胶质瘤分级具有良好的诊断效能。

关键词: 脑胶质瘤, 肿瘤分级, MRI参数, 白细胞介素-10, 血管内皮生长因子