Abstract: Objective To analyze the efficacy and influencing factors of high-frequency repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression.Methods The clinical data of 80 patients with depression who were given drug therapy combined with high-frequency rTMS admitted to the Affiliated Hospital of Wanxi Health Vocational College were retrospectively analyzed between May 2019 and May 2022,and the patients were classified as the study group.Another 80 patients with depression who only adopted drug therapy during the same period were used for controls,and they were set as the control group.Hamilton Depression Scale (HAMD) was used to evaluate the depressive symptoms of patients after treatment,and the treatment effect was compared.The patients in the study group were divided into effective treatment group (n=51) and ineffective treatment group (n=29) according to the changes in HAMD score after treatment.Univariate comparison was performed on clinical data such as gender,age,education level,family history of mental illness,disease course,sleep status,exercise status,treatment compliance,quality of life,family intimacy,cognitive ability and combined physical diseases,and unconditional Logistic multivariate stepwise regression analysis was performed on indicators with significant differences to analyze the influencing factors affecting the efficacy of high-frequency rTMS in the treatment of patients with depression.Results The effective rate of drug therapy combined with high-frequency rTMS treatment was 63.75%,and the efficacy of the study group was significantly higher than that of the control group (P＜0.05).Sleep status,treatment compliance,family intimacy and cognitive ability were all independent factors that affected the efficacy of high-frequency rTMS in the treatment of depression (all P＜0.05).Conclusion Drug therapy combined with high-frequency rTMS has a high efficacy in the treatment of depression,and the sleep status,treatment compliance,family intimacy and cognitive ability during treatment are the influencing factors of its efficacy.In clinical practice,corresponding intervention measures can be implemented according to the influencing factors so as to improve the prognosis of patients.

Key words: High-frequency repetitive transcranial magnetic stimulation, Depression, Efficacy, Influencing factors

摘要： 目的 分析高频重复经颅磁刺激(rTMS)治疗抑郁症疗效及影响因素。方法 回顾性分析皖西卫生职业学院附属医院2019年5月~2022年5月使用药物治疗联合高频rTMS治疗的80例抑郁症患者的临床资料,将其归为研究组,再以同期仅使用药物治疗的80例抑郁症患者为对照,将其归为对照组。使用汉密尔顿抑郁量表(HAMD)对治疗后患者抑郁症状进行评估,比较两组治疗效果,再根据治疗后患者HAMD评分变化将研究组分为治疗有效组(n=51)和治疗无效组(n=29),对患者性别、年龄、文化程度、精神病家族史、病程、睡眠情况、运动情况、治疗依从性、生活质量、家属亲密度、认知能力、合并躯体疾病等临床资料进行单因素比较,选取存在显著差异的指标行非条件Logistic多元逐步回归分析,分析影响高频rTMS治疗抑郁症患者疗效的影响因素。结果 药物治疗联合高频rTMS治疗有效率为63.75%,研究组疗效明显高于对照组(P＜0.05)。睡眠情况、治疗依从性、家属亲密度、认知能力均是影响高频rTMS治疗抑郁症疗效的独立因素(P均<0.05)。结论 药物治疗联合高频rTMS治疗抑郁症具有较高疗效,且治疗期间患者睡眠情况、治疗依从性、家属亲密度和认知能力均为其疗效的影响因素,临床上可根据其影响因素实施相应干预手段,以改善患者预后。

关键词: 高频重复经颅磁刺激, 抑郁症, 疗效, 影响因素