doi:10.19854/j.cnki.1008-2425.2023.03.0011

Abstract

摘要： 脑室周围结节型异位(periventricular nodular heterotopia,PNH)是一种由神经元细胞迁移障碍引起的脑发育畸形病,表现为脑室周围存在结节状的异位灰质。PNH可能是由于相关基因的突变所致。在PNH的MRI图像上可以看见脑室周围存在结节状异位灰质,其信号强度与大脑皮质一致。功能磁共振等影像学技术也开始应用于PNH的研究,并取得了一定的成果。PNH最常见的临床症状为癫痫,因此如何确定致癫区和切断其癫痫样电活动传播是治疗的关键,脑电图(EEG)技术成为了诊断PNH相关癫痫的必不可少的方法,特别是立体定向脑电图(SEEG)技术的出现使得癫痫的诊疗方面有了极大地进步。PNH所致的难治性癫痫的的外科治疗包括传统切除手术、射频热凝治疗(radiofrequency thermal coagulation,RF-TC)和激光间质内热凝(laserinterstitial thermal therapy LITT),目前以RF-TC为主要的治疗方式。

关键词: 灰质异位, 脑室周围结节型异位, 癫痫, 基因, 影像学, 脑电图, 临床症状, 外科治疗

CLC Number:

R742.1

田川, 王小强, 兰正波, 史雪峰, 杨宝慧, 李正斌, 张新定. 脑室周围结节型灰质异位所致癫痫的诊疗的研究进展[J]. 立体定向和功能性神经外科杂志, 2023, 36(3): 186-192.

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脑室周围结节型灰质异位所致癫痫的诊疗的研究进展

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