Analysis of the efficacy of GPi-DBS on non-motor symptoms and quality of life in segmental craniocervical dystonia

doi:10.19854/j.cnki.1008-2425.2023.01.0002

Abstract

Abstract: Objective To investigate the therapeutic effect of Globus pallidus internus-Deep brain stimulation (GPi-DBS) in the treatment of segmental craniocervical dystonia (SCCD) non-motor symptoms (NMS) and the improvement of quality of life (QoL).Methods A total of 16 patients undergoing GPi-DBS surgery for SCCD from March 2020 to June 2021 were collected and assessed for motor symptoms,non-motor symptoms,depression,anxiety and quality of life using the BFMDRS scale,DNMSQuest questionnaire,HAM-D scale,HAM-A scale and CDQ-24 questionnaire before surgery and at the 1st,3rd,6th,12th and 18th months after postoperative onset.Pre-operative and post-operative patients were analyzed for differences,and NMS was correlated with QoL.Results Patients had a significant reduction in NMS and improvement in QoL after surgery compared to the preoperative period (P<0.05).The patients showed a significant correlation between each NMS and QoL (P<0.01).Conclusion GPi-DBS was effective in treating NMS in SCCD,and QoL could be significantly improved,and NMS was significantly correlated with QoL.

Key words: Globuspallidusinternus-Deepbrainstimulation, Segmental craniocervical dystonia, Non-motor symptoms, Quality of life

摘要： 目的研究苍白球内侧部脑深部电刺激术(Globuspallidusinternus-Deepbrainstimulation,GPi-DBS)对节段性颅颈肌张力障碍(Segmental Craniocervical Dystonia,SCCD)非运动症状(Non Motor Syndrome,NMS)的治疗效果及对生活质量(quality of life,QoL)的改善程度。方法收集2020年3月至2021年6月共16名进行GPi-DBS手术治疗SCCD的病人,在术前及术后开机后第1,3,6,12,18个月,均使用BFMDRS量表,DNMSQuest问卷,HAM-D量表,HAM-A量表以及CDQ-24问卷,分别评估患者的运动症状,非运动症状,抑郁,焦虑水平以及生活质量。术前与术后行差异性分析,NMS与QoL行相关性分析。结果患者术后NMS较术前显著缓解,QoL也较术前改善(P＜0.05)。患者的各项NMS与QoL呈现显著相关性(P＜0.01)。结论 GPi-DBS治疗SCCD的NMS效果显著,QoL可获得显著改善,NMS与QoL显著相关。

关键词: 苍白球内侧部脑深部电刺激术, 节段性颅颈肌张力障碍, 非运动症状, 生活质量

CLC Number:

R746

YiliyasijiangMaimaitituerxun, Jiang Lei, FengZhaohai, et al. Analysis of the efficacy of GPi-DBS on non-motor symptoms and quality of life in segmental craniocervical dystonia[J]. Chinese Journal of Stereotactic and Functional Neurosurgery, 2023, 36(1): 7-12.

依利亚斯江·买买提吐尔逊, 姜磊, 冯兆海, 王西宪, 裴祎楠, 买买提江·卡斯木. GPi-DBS对节段性颅颈肌张力障碍的非运动症状与生活质量的疗效分析[J]. 立体定向和功能性神经外科杂志, 2023, 36(1): 7-12.

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