Abstract: Objective To investigate the application of intraoperative wake-up anesthesia technique based on accelerated rehabilitation surgery (ERAS) in patients with glioma and its effects on the extent of tumor resection,postoperative language and motor function.Methods 159 patients with glioma in our hospital from January 2020 to January 2022 were selected and grouped differently according to the order of admission and establishment,with the observation group adopting intraoperative arousal anesthesia technique based on ERAS,the control A group adopting intraoperative arousal anesthesia technique,and the control B group receiving conventional anesthesia management.The surgery-related indexes,degree of tumor resection and pre- and post-operative speech function,motor function,quality of life and postoperative complications were compared among the three groups.Results When comparing the bleeding volume and operation time of the three groups,there was no significant difference (P＞0.05);the ICU supervision and postoperative hospitalization time of the observation group were shorter than those of the control A and B groups (P＜0.05);when comparing the degree of tumor resection of the three groups,the difference was not statistically significant (P＞0.05);the VFT,BNT,and ABC scores of the observation group were higher than those of the control A and B groups,and those of the control A group were higher than those of the control B group 1 month after surgery (P<0.05);Fugl-Meye and ADL scores were higher in the observation group than in control groups A and B,and higher in control group A than in control group B at 1 month after surgery (P<0.05);EORTCQLQ-C30 scores were higher in the observation group than in control groups A and B,and higher in control group A than in control group B at 1 month after surgery (P<0.05).Complication rates in the three groups were not statistically significant compared with each other (P>0.05).Conclusion In ERAS-based arousal anesthesia technique applied to patients with glioma can promote early postoperative recovery,improve language and motor function,and enhance the level of survival quality.

Key words: Accelerated rehabilitation surgery, Arousal anesthesia technique, Glioma, Degree of tumor resection, Language function, Motor function

摘要： 目的 探讨基于加速康复外科(ERAS)的术中唤醒麻醉技术在脑胶质瘤患者中的应用及其对肿瘤切除程度、术后语言及运动功能的影响。方法 选取2020年1月～2022年1月我院159例脑胶质瘤患者,根据入院建档顺序不同分组,观察组采取基于ERAS的术中唤醒麻醉技术,对照A组采取术中唤醒麻醉技术,对照B组接受常规麻醉管理。比较三组手术相关指标、肿瘤切除程度及手术前后语言功能、运动功能、生活质量、术后并发症。结果 三组出血量、手术时间比较,无显著差异(P＞0.05);观察组ICU监护及术后住院时间均短于对照A、B组(P＜0.05);三组肿瘤切除程度相比,差异无统计学意义(P＞0.05);术后1个月观察组VFT、BNT、ABC评分高于对照A、B组,对照A组高于对照B组(P＜0.05);术后1个月观察组Fugl-Meye、ADL评分高于对照A、B组,对照A组高于对照B组(P＜0.05);术后1个月观察组EORTCQLQ-C30评分高于对照A、B组,对照A组高于对照B组(P＜0.05)。三组并发症发生率相比,差异无统计学意义(P＞0.05)。结论 基于ERAS的唤醒麻醉技术应用于脑胶质瘤患者,可促进术后早期康复,改善语言及运动功能,提升生存质量水平。

关键词: 加速康复外科, 唤醒麻醉技术, 脑胶质瘤, 肿瘤切除程度, 语言功能, 运动功能