Abstract: Objective To investigate the longitudinal study of the factors influencing the fear of disease progression disease in patients with first diagnosis of Parkinson's. Methods This study is a longitudinal study,selecting patients admitted to our hospital from January 2020 to December 2023 with a clear first diagnosis of Parkinson's as the study object,using the general information questionnaire respectively in the first for the first diagnosis (T1),2 months after diagnosis (T2),4 months after diagnosis (T3),6 months after diagnosis (T4) tracking follow-up survey,to identify first diagnosis of Parkinson's with latent category modeling patients' fear of disease progression change trajectories,and logistic regression was used to analyze the factors influencing patients' fear of disease progression trajectories. Results A total of 2 trajectories of change in fear of disease progression scores were identified based on the first diagnosis of Parkinson's patients,59.35% (92/155) in the high level fear of disease progression slow decline group,and 40.65% (63/155) in the medium level fear of disease progression stable group.The results of the logistic regression analysis showed that,using the medium-stable group as a reference,the patients in the high fear of disease progression slow Age,PSQI score,H&Y grading,HAMA score,and levodopa treatment of patients in the descending group were influential factors affecting the category of fear of disease progression trajectory in patients with first diagnosis of Parkinson's (P＜0.05). Conclusion Age >70 years,PSQI score ≥5,H&Y score 3-5,HAMA score >14,and no levodopa treatment are influential factors affecting the category of fear of disease progression trajectory in first-diagnosis Parkinson's patients,and it is recommended that interventions be targeted according to the above risk factors.

Key words: First diagnosis, Parkinson's, Fear of disease progression, Influencing factors, Longitudinal study

摘要： 目的 探究首诊帕金森患者恐惧疾病进展疾病影响因素的纵向研究。方法 本研究为纵向研究,选择2020年1月~2023年12月于我院收治并明确首诊为帕金森患者为研究对象,采用一般资料问卷调查表分别于第一次为首次确诊(T1)、确诊后2个月(T2)、确诊后4个月(T3)、确诊后6个月(T4)追踪随访调查,以潜类别模型识别首诊帕金森病患者恐惧疾病进展变化轨迹,并用Logistic回归分析患者恐惧疾病进展轨迹的影响因素。结果 根据首诊帕金森病患者恐惧疾病进展得分变化轨迹共识别出2条,高水平疾病进展恐惧缓慢下降组占比59.35%(92/155),中水平恐惧疾病进展稳定组占比40.65%(63/155)。Logistic回归分析结果显示,以中-稳定组作为参照物,高疾病进展恐惧缓慢下降组患者年龄、PSQI评分、H＆Y 分级、HAMA评分、左旋多巴治疗均是影响首诊帕金森患者恐惧疾病进展轨迹类别的影响因素(P＜0.05)。结论 年龄＞70岁、PSQI评分≥5分、H＆Y 分级3~5级、HAMA评分＞14分、未进行左旋多巴治疗均是影响首诊帕金森患者恐惧疾病进展轨迹类别的影响因素,建议根据以上危险因素进行针对性地干预。

关键词: 首诊, 帕金森, 恐惧疾病进展, 影响因素, 纵向研究