Abstract: Objective To investigate the changes and significance of resting EEG power spectral density and coherence in patients with migraine (MP). Methods 45 patients with interphase migraine without aura diagnosed in the outpatient of Neurology department of the First Affiliated Hospital of University of Science and Technology of China from January 2022 to June 2022 were included in the migraine group (MP) and 45 healthy subjects in our hospital during the same period were included in the control group (HC).The resting state EEG signals and related clinical indexes were collected.The EEG power spectral density and coherence at different frequency bands δ(1-3.9Hz),θ(4-7.9Hz),α(8-12.9Hz) and β(13-29.9Hz)　of 19 channels in the two groups were calculated,and the statistical differences of the above indexes were compared between the two groups. Results Power spectrum analysis showed that compared with HC group,EEG power spectrum density of δ band in FP1 and FP2 channels in MP group decreased,and all channels in θ,α and β bands in MP group were decreased,and the differences were statistically significant (correction P＜0.05).Compared with HC group,the average EEG power spectral density of the whole brain in θ,α and β bands except for the δ band were significantly decreased in MP group,and the differences were statistically significant (correction P＜0.05).Coherence analysis showed that there are a large number of edges with weakened connection on the frontal parietal temporal occipitoparietal in θ,α and β bands in MP group,while there are a few weakened edges in δ band.The differences were statistically significant (correction P＜0.05).There is no edge with enhanced connection in δ,θ,α and β bands in MP group.(correction P＞0.05). Conclusion There are abnormalities of EEG power and coherence in migraine patients.It provides new insight for diagnosis and treatment of Migraine in future.

Key words: Migraine, Electroencephalogram, Power spectral density, Coherence

摘要： 目的 探讨偏头痛患者( MP)发作间期静息态脑电功率谱密度和相干的变化及其意义。方法 纳入2022年1月至2022年6月中国科学技术大学附属第一医院神经内科门诊确诊的45例无先兆发作间期偏头痛患者为偏头痛组(MP)及45名我院同期健康体检者为对照组(HC)。采集两组受试者静息态脑电数据及相关临床指标。计算两组19通道不同频段δ(1-3.9 Hz)、θ(4-7.9 Hz)、α(8-12.9 Hz)和β(13-29.9 Hz)的脑电功率谱密度和相干,并比较两组上述指标统计学差异。结果 功率谱分析显示,与HC组比较,MP组δ频段在FP1和FP2通道的脑电功率谱密度降低,θ、α和β频段所有通道的脑电功率谱密度均降低,差异有统计学意义(校正P＜0.05)。与HC组比较,MP组δ频段全脑平均脑电功率谱密度未见明显改变,θ、α和β频段全脑平均脑电功率谱密度降低,差异有统计学意义(校正P＜0.05)。相干分析显示,MP组θ、α和β频段额颞顶枕区存在大量连接减弱的边,δ频段有较少连接减弱的边。各频段所有通道均无连接增强的边(校正P＜0.05)。结论 偏头痛患者发作间期存在脑电功率和相干的异常改变,为偏头痛临床诊治提供新的思路。

关键词: 偏头痛, 脑电图, 功率谱密度, 相干