Abstract: Objective To explore the risk factors of postoperative fever in patients with glioma and provide reference for clinical nursing practice.Methods We retrospetively collected 102 patients with glioma who underwent neurosurgical operations.Clinicopathological factors including age,sex,tumor size,operation duration,diabetes,ventricle opening,pneumonia and Intracranial infection were collected.T test or chi-square test were used for univariate analysis.Multivariate logistic regression analysis was used for further assessment of the independence of the factors.Results Among the 102 patients,37 patients had significant postoperative fever (body temperature ≥38.5℃).Univariate difference analysis showed that there were no significant differences in gender,age,tumor size,diabetes or not,and operation duration between the group with postoperative fever and the group without postoperative fever.In the group with fever,there were more postoperative pulmonary infections (P=0.039) and intracranial infections (P<0.001),and a larger proportion of patients with intraoperative ventricle opening (P=0.004).Ventricular opening increased the risk of intracranial infection (P=0.026).Multivariate Logistic analysis showed that intraoperative ventricle opening and pulmonary infection were independent influencing factors of postoperative fever (P=0.003,P=0.031).Conclusion Intraoperative ventricle opening,postoperative pulmonary infection and intracranial infection may be the influencing factors of postoperative fever in patients with glioma.

Key words: Neurosurgery, Glioma, Fever, Risk factor

摘要： 目的 探讨胶质瘤患者术后发热的影响因素,为临床护理实践提供借鉴。方法 回顾性分析102例胶质瘤患者行手术切除的临床及病理资料,包括患者年龄、性别、肿瘤大小、手术时长、有无糖尿病、是否术中脑室开放、术后是否肺部感染及颅内感染共8项内容。应用t检验或χ²检验比较术后发热患者与无发热患者上述因素的差异,应用多因素Logistic回归分析上述因素与术后发热的相关关系。结果 102例患者中,术后明显发热(体温≥38.5℃)患者37例。单因素差异分析发现,术后发热组与术后无发热组间性别、年龄、肿瘤大小、是否有糖尿病及手术时长无统计学差异,发热组术后肺部感染(P=0.039)及颅内感染更多(P<0.001)、术中脑室开放患者比例更大(P=0.004)。脑室开放增加了颅内感染的风险(P=0.026)。多因素Logistic分析发现,术中脑室开放及肺部感染是患者术后发热的独立影响因素(P=0.003,P=0.031)。结论 术中脑室开放、术后肺部感染及颅内感染可能是胶质瘤患者术后发热的影响因素。

关键词: 神经外科, 胶质瘤, 发热, 危险因素