Abstract: Objective To explore the value of the relevant parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) in the preoperative diagnosis of astrocytoma.Methods The 48 patients with astrocytomaadmitted to our hospital from October 2019 to October 2021 were selected as the study subjects.The patients were classified into low-grade astrocytic tumours (n=20) and high-grade astrocytic tumours (n=28).The volume transport parameters (K^trans),extravascular extracellular space volume ratio (V_e),apparent diffusion coefficient (ADC) in patients with different grades were measured and compared.The ROC curve was used to assess the value of K^trans,Ve,and ADC to predict high-grade astrocytoma.Results The K^trans values,V_e of patients with low-grade astrocytoma were significantly lower than those with high-grade astrocytoma,and ADC was significantly higher than that of patients with high-grade astrocytoma (P＜0.05).After ROC analysis,the area under the curve of K^trans,V_e,and ADC predicting high-grade astrocytoma were 0.756、0.823、0.694 (all P＜0.05),respectively.Conclusion DCE-MRI and DWI preoperative diagnosis of astrocytoma parameters are related to malignant degree of astrocytoma patients,which can provide a reference for the implementation of surgery,treatment program and prognostic evaluation.

Key words: Dynamic contrast-enhanced magnetic resonance imaging, Brain astrocytoma, Volume transport parameters, Extravascular extracellular space volume ratio, Apparent diffusion coefficient

摘要： 目的 探讨动态对比增强磁共振成像(DCE-MRI)和弥散加权成像(DWI)相关参数在术前评估脑星形细胞瘤恶性程度分级的价值。方法 回顾性分析我院2019年10月～2021年10月经病理证实的48例脑星形细胞瘤患者,其中低级别星形细胞瘤20例,高级别星形细胞瘤28例。比较不同分级患者容积转运参数(K^trans)、血管外细胞外间隙容积比(V_e)、表观扩散系数(ADC)。通过ROC分析K^trans值、V_e、ADC预测高级别脑星形细胞瘤的价值。结果 低级别脑星形细胞瘤患者K^trans值、V_e显著低于高级别脑星形细胞瘤患者,ADC显著高于高级别脑星形细胞瘤患者(P＜0.05)。经过ROC分析,K^trans值、V_e、ADC预测高级别星形细胞瘤的曲线下面积分别为0.756、0.823、0.694(均P＜0.05)。结论 DCE-MRI联合DWI术前诊断脑星形细胞瘤相关参数和病变恶性程度相关,可为手术实施、治疗方案和预后评估提供参考。

关键词: 动态对比增强磁共振成像, 脑星形细胞瘤, 容积转运参数, 血管外细胞外间隙容积比, 表观扩散系数