关键词: 迷走神经电刺激, 药物难治性癫痫, 疗效

Abstract: Objective This study aims to evaluate the efficacy of Vagus Nerve Stimulation (VNS) in treating drug-resistant epilepsy in adolescents and adults through a multicenter,large-sample clinical trial.The goal is to provide evidence for the clinical application of this therapy in China and to explore its long-term efficacy. Methods This study recruited 206 patients with drug-resistant epilepsy from nine epilepsy centers across China between January 2022 and November 2024.All participants underwent VNS treatment and were followed up at 3,6,and 12 months post-surgery to record the frequency of epileptic seizures.Statistical analysis was performed using SPSS software. Results The results showed a 33.34% reduction in seizure frequency at the 3-month follow-up;at 6 and 12 months,the reduction rates were 40.36% and 51.26%,respectively.The proportion of patients with over a 50% improvement in seizure frequency was 23.79% at 3 months,40.80% at 6 months,and 53.77% at 12 months post-surgery. Conclusion This study demonstrates that VNS has significant therapeutic effects on drug-resistant epilepsy,particularly with increasing seizure reduction rates at 6 and 12 months post-treatment.The findings support the clinical application of VNS in China and emphasize the importance of long-term follow-up and personalized treatment adjustments for optimal efficacy.

Key words: Vagus nerve stimulation, Drug-resistant epilepsy, Outcome