关键词: 偏头痛, 脑电图, 功率谱密度, 相干

Abstract: Objective To investigate the changes and significance of resting EEG power spectral density and coherence in patients with migraine (MP). Methods 45 patients with interphase migraine without aura diagnosed in the outpatient of Neurology department of the First Affiliated Hospital of University of Science and Technology of China from January 2022 to June 2022 were included in the migraine group (MP) and 45 healthy subjects in our hospital during the same period were included in the control group (HC).The resting state EEG signals and related clinical indexes were collected.The EEG power spectral density and coherence at different frequency bands δ(1-3.9Hz),θ(4-7.9Hz),α(8-12.9Hz) and β(13-29.9Hz)　of 19 channels in the two groups were calculated,and the statistical differences of the above indexes were compared between the two groups. Results Power spectrum analysis showed that compared with HC group,EEG power spectrum density of δ band in FP1 and FP2 channels in MP group decreased,and all channels in θ,α and β bands in MP group were decreased,and the differences were statistically significant (correction P＜0.05).Compared with HC group,the average EEG power spectral density of the whole brain in θ,α and β bands except for the δ band were significantly decreased in MP group,and the differences were statistically significant (correction P＜0.05).Coherence analysis showed that there are a large number of edges with weakened connection on the frontal parietal temporal occipitoparietal in θ,α and β bands in MP group,while there are a few weakened edges in δ band.The differences were statistically significant (correction P＜0.05).There is no edge with enhanced connection in δ,θ,α and β bands in MP group.(correction P＞0.05). Conclusion There are abnormalities of EEG power and coherence in migraine patients.It provides new insight for diagnosis and treatment of Migraine in future.

Key words: Migraine, Electroencephalogram, Power spectral density, Coherence