IL-37在不同级别胶质瘤组织中的表达及其与预后的相关性

doi:10.19854/j.cnki.1008-2425.2021.06.0008

立体定向和功能性神经外科杂志 ›› 2021, Vol. 34 ›› Issue (6): 353-357.DOI: 10.19854/j.cnki.1008-2425.2021.06.0008

IL-37在不同级别胶质瘤组织中的表达及其与预后的相关性

王志丹, 依斯哈尔巴拉提, 阿卜力克木·伊敏江, 迪里夏提·依马木, 巴高

830000 新疆新疆维吾尔自治区儿童医院神经外科(王志丹、依斯哈尔巴拉提、阿卜力克木·伊敏江、迪里夏提·依马木);普外科(巴高)

收稿日期:2021-09-25 发布日期:2022-04-18
通讯作者: 巴高 251184046@qq.com
基金资助:
新疆维吾尔自治区自然科学基金项目(编号:2016D01C116)

Expression of IL-37 in different grades of gliomas and its correlation with prognosis

Wang ZhiDan, YiSiHaErBaLaTi, ABuLiKeMu·YiMinJiang, et al.

1. Neurosurgery department,2. General surgery department,Children's Hospital of Xinjiang Uygur Autonomous Region,Xinjiang 830000,China

Received:2021-09-25 Published:2022-04-18

摘要/Abstract

摘要： 目的分析IL-37在不同级别胶质瘤中的表达差异及其预后的相关性。方法收集2016年3月至2020年9月于我院收治的66例不同类型、不同级别的胶质瘤患者的组织标本和临床病理资料,对照组为10例颅脑外伤后行颅内减压手术切除的脑组织。应用实时荧光定量PCR(RT-PCR)和免疫组化技术检测脑胶质瘤组织中IL-37mRNA和蛋白质的表达,评估IL-37表达与各种临床病理因素之间的相关性。结果 IL-37mRNA在正常组织和胶质瘤组织中均有表达,胶质瘤组织中IL-37mRNA表达明显高于正常组织(P＜0.01)。IL-37表达随WHO分级升高而下降。IL-37在恶性程度高的胶质瘤组织表达比恶性程度低的胶质瘤组织显著降低,IL-37低表达的患者生存时间较短。结论 L-37低表达与病理分级呈负相关,低IL-37与生存时间呈正相关。因此,IL-37可能在胶质瘤的进展中起到抑制作用。

关键词: IL-37, 胶质瘤, 预后

Abstract: Objective To analyze the expression of IL-37 in different grades of gliomas and its correlation with prognosis.Methods The tissue specimens and clinicopathological data were collected from 66 patients with different types and grades of gliomas were treated in Our hospital from March 2016 to September 2020.The control group consisted of 10 normal brain tissues after craniocerebral trauma underwent intracranial decompression surgery.The expression of IL-37 mRNA and protein was detected by real-time PCR and immunohistochemistry,and the correlation between IL-37 expression and various clinicopathological factors was evaluated.Results The expression of IL-37 mRNA in glioma was significantly higher than that in normal tissue (P<0.01).The expression of IL-37 decreased with the increase of who grade.The expression of IL-37 in gliomas with high degree of malignancy was significantly lower than that in gliomas with low degree of malignancy.The survival time of patients with low expression of IL-37 was shorter.Conclusion Low expression of IL-37 was negatively correlated with pathological grade,and low expression of IL-37 was positively correlated with survival time.Therefore,IL-37 may play an inhibitory role in the progression of glioma.

Key words: IL-37, Glioma, Prognosis

中图分类号:

R739.41

王志丹, 依斯哈尔巴拉提, 阿卜力克木·伊敏江, 迪里夏提·依马木, 巴高. IL-37在不同级别胶质瘤组织中的表达及其与预后的相关性[J]. 立体定向和功能性神经外科杂志, 2021, 34(6): 353-357.

Wang ZhiDan, YiSiHaErBaLaTi, ABuLiKeMu·YiMinJiang, et al.. Expression of IL-37 in different grades of gliomas and its correlation with prognosis[J]. Chinese Journal of Stereotactic and Functional Neurosurgery, 2021, 34(6): 353-357.

参考文献

[1] Gusyatiner O,Hegi ME.Glioma epigenetics:From subclassification to novel treatment options[J].J Semin Cancer Biol,2018,51(1):50~58.
[2] Jia H,Jing L,Han B .Reviews of Interleukin-37:Functions,Receptors,and Roles in Diseases [J].J BioMed Research International,2018,2018(1):1~14.
[3] Sánchez-Fernández A,Zandee S,Amo-Aparicio J,Charabati M,Prat A,Garlanda C,Eisenmesser EZ,Dinarello CA,López-Vales R.IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8[J].J Theranostics, 2021,11(1):1~13.
[4] Bai J,Li Y,Li M,Tan S,Wu D.IL-37 As a Potential Biotherapeutics of Inflammatory Diseases[J].J Curr Drug Targets,2020,21(9):855~863.
[5] Wang L,Quan Y,Yue Y,Heng X,Che F.Interleukin-37:A crucial cytokine with multiple roles in disease and potentially clinical therapy[J].J Oncol Lett,2018,15(4):4711~4719.
[6] Chen YH,Zhou BY,Wu GC,Liao DQ,Li J,Liang SS,et al.Effects of exogenous IL-37 on the biological characteristics of human lung adenocarcinoma A549 cells and the chemotaxis of regulatory T cells[J].J Cancer Biomark,2018,21(3):661~673.
[7] Jiang M,Wang Y,Zhang H,Ji Y,Zhao P,Sun R,et al.IL-37 inhibits invasion and metastasis in nonsmall cell lung cancer by suppressing the IL-6/STAT3 signaling pathway[J].J Thorac Cancer, 2018,9(5):621~962.
[8] Jing L,Kim S,Sun L,Wang L,Mildner E,Divaris K,Jiao Y,Offenbacher S.IL-37- and IL-35/IL-37-Producing Plasma Cells in Chronic Periodontitis[J].J Dent Res,2019,98(7):813~821.
[9] Meng JP,Luo P,Bai Y,Cui F.Entecavir downregulates interleukin-37 in patients with chronic active hepatitis B infection[J].J Int Med Res,2020,48(1):300060519884157.
[10] Mantovani A,Barajon I,Garlanda C.IL-1 and IL-1 regulatory pathways in cancer progression and therapy[J].J Immunol Rev,2018,281(1):57~61.
[11] Pan Y,Wen X,Hao D,Wang Y,Wang L,He G,Jiang X.The role of IL-37 in skin and connective tissue diseases[J].J Biomed Pharmacother,2020,122(1):109705.
[12] Mountford S,Ringleb A,Schwaiger R,Mayr D,Kobold S,Dinarello CA,Bufler P.Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis[J].J Front Immunol,2019,8(10):2632.
[13] Mountford S,Effenberger M,Noll-Puchta H,Griessmair L,Ringleb A,Haas S,Denk G,Reiter FP,Mayr D,Dinarello CA,Tilg H,Bufler P.Modulation of Liver Inflammation and Fibrosis by Interleukin-37[J].J Front Immunol,2021,12(1):603~649.
[14] Shi H,Fang X,Li Y,Zhang Y.High Expression of Serine Hydroxymethyltransferase 2 Indicates Poor Prognosis of Gastric Cancer Patients[J].J Med Sci Monit,2019,25(1):7430~7438.
[15] Zhang J,Cai H,Sun L,Zhan P,Chen M,Zhang F,Ran Y,Wan J.LGR5,a novel functional glioma stem cell marker,promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients[J].J Exp Clin Cancer Res,2018,37(1):225.
[16] Cavalli G,Dinarello CA.Suppression of inflammation and acquired immunity by IL-37[J].J Immunol Rev,2018,281(1):179~190.
[17] Abulkhir A,Samarani S,Amre D,Duval M,Haddad E,Sinnett D,et al.A protective role of IL-37 in cancer:a new hope for cancer patients[J].J Leukoc Biol,2017,101(2):395~406.[18] Li TT,Zhu D,Mou T,Guo Z,Pu JL,Chen QS,et al.IL-37 induces autophagy in hepatocellular carcinoma cells by inhibiting the PI3K/AKT/mTOR pathway[J].J Mol Immunol,2017,87(1):132~140.
[19] Zhang Z,Zhang J,He P,Han J,Sun C.Interleukin-37 suppresses hepatocellular carcinoma growth through inhibiting M2 polarization of tumor-associated macrophages[J].J Mol Immunol,2020,122(1):13~20.
[20] Li P,Guo H,Wu K,Su L,Huang K,Lai R,Deng Z,Li S,Ouyang P,Wang Y,Chen Z,Zhou G,Wang S.Decreased IL-37 expression in hepatocellular carcinoma tissues and liver cancer cell lines[J].J Oncol Lett,2020,19(4):2639~2648.
[21] Mei Y,Liu H.IL-37:An anti-inflammatory cytokine with antitumor functions[J].J Cancer Rep (Hoboken),2019,2(2):e1151.
[22] Zhang Y,Tang M,Wang XG,Gu JH,Zhou LN,Jin J,et al.Elevated serum levels of interleukin-37 correlate with poor prognosis in gastric cancer[J].J Rev Esp Enferm Dig,2019,111(12):941~945.
[23] Yan X,Zhao J,Zhang R.Interleukin-37 mediates the antitumor activity in colon cancer through β-catenin suppression[J].J Oncotarget,2017,8(30):49064~75.

IL-37在不同级别胶质瘤组织中的表达及其与预后的相关性

Expression of IL-37 in different grades of gliomas and its correlation with prognosis

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