帕金森病患者双侧丘脑底核脑深部电刺激术后2年非运动症状的研究

doi:10.19854/j.cnki.1008-2425.2023.04.0001

立体定向和功能性神经外科杂志 ›› 2023, Vol. 36 ›› Issue (4): 193-199.DOI: 10.19854/j.cnki.1008-2425.2023.04.0001

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帕金森病患者双侧丘脑底核脑深部电刺激术后2年非运动症状的研究

王珏, 邱娴, 高颖, 寿文华, 徐露, 李殿友, 王林斌, 孙伯民, 朱大乔

200025 上海上海交通大学医学院附属瑞金医院护理部(王珏,邱娴,寿文华);上海交通大学护理学院(王珏,邱娴,高颖,朱大乔);上海交通大学医学院附属瑞金医院神经外科,上海交通大学医学院附属瑞金医院功能神经外科中心(王珏,邱娴,寿文华,徐露,李殿友,王林斌,孙伯民)

收稿日期:2023-05-10 出版日期:2023-08-25 发布日期:2023-10-12
通讯作者: 朱大乔 zhudaqiao@aliyun.com
基金资助:
2022上海交通大学医学院附属瑞金医院护理科研基金项目(编号:RJHK-2022-6);2022年度上海交通大学医学院护理科研面上项目(编号:Jyh2203);上海高水平地方高校创新团队建设项目(编号:SHSMU-ZDCX20212801);上海交通大学医学院护理学科人才建设项目(编号:SJTUHLXK2021);上海申康医院发展中心临床科技创新项目(编号:SHDC-12021625)

A two-year survey on non-motor symptoms after bilateral subthalamic nucleus deep brain stimulation in patients with Parkinson's disease

Wang Jue, Qiu Xian, Gao Ying, et al

Wang Jue, Qiu Xian, Gao Ying, et al. Department of Nursing, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;Wang Jue, Qiu Xian, Zhu Daqiao, et al.School of Nursing, Shanghai Jiao Tong University, Shanghai 200025, China;Wang Jue, Qiu Xian, Shou Wenhua, et al.Department of Neurosurgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University;Center of Functional Neurosurgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China

Received:2023-05-10 Online:2023-08-25 Published:2023-10-12

摘要/Abstract

摘要： 目的了解帕金森病患者行双侧丘脑底核脑深部电刺激术(STN-DBS)后非运动症状及生活质量的变化情况。方法采取便利抽样法,对上海交通大学医学院附属瑞金医院功能神经外科中心2020年6月1日至2020年8月31日符合双侧STN-DBS疗法适应证的帕金森病患者45人进行问卷调查,运用患者一般资料调查表、非运动症状量表(NMSS)及8项帕金森病调查表(PDQ-8)对患者术前及术后3个月、6个月、12个月及24个月时非运动症状及生活质量的情况进行评估与分析。结果经广义估计方程分析发现,患者术后PDQ-8、左旋多巴每日等效剂量(LEDD)的5次随访的整体变化是具有统计学意义的(P＜0.05),NMSS中,心血管维度和感知障碍维度的整体变化没有统计学意义(P＞0.05),而睡眠/疲劳、情绪/冷漠、注意力/记忆、胃肠道症状、泌尿系统症状、性功能及混合症状的整体变化均具有统计学意义(P＜0.05)。结论双侧STN-DBS术可长期改善帕金森病患者的睡眠/疲劳及泌尿系统症状;在短期内改善情绪/冷漠、注意力/记忆及性功能;对胃肠道症状及混合症状均具有一定的改善作用;同时可减少患者药物治疗的剂量,提高患者的生活质量。

关键词: 帕金森病, 脑深部电刺激, 非运动症状, 生活质量, 纵向研究

Abstract: Objective To investigate the changes of non-motor symptoms and quality of life in patients with Parkinson's disease (PD) after bilateral subthalamic nucleus deep brain stimulation (STN-DBS).Methods Questionnaires were conducted among a convenience sample of 45 PD patients who met the indications of STN-DBS in the Functional Neurosurgery Center of Ruijin Hospital,Shanghai JiaoTong University School of Medicine in Shanghai from June 1,2020 to August 31,2020.The Non-motor Symptom Scale (NMSS) and 8-item Parkinson's Disease Questionnaire (PDQ-8) were used to evaluate the patients' non-motor symptoms and quality of life preoperatively and at 3,6,12 and 24-month postoperative visits.Results Generalized estimation equation analysis showed a significant overall change of PDQ-8 and levodopa equivalent daily dose (LEDD) over five follow-up visits (P＜0.05).Sleep/fatigue,Mood/apathy,Attention/memory,Gastrointestinal,Urinary,Sexual function and Miscellaneous subscores showed a statistically significant decreasing trend (P＜0.05),while Cardiovascular and Perceptual subscores of NMSS were unchanged (P>0.05).Conclusion Bilateral STN-DBS has a long-term benefit on sleep/fatigue and urinary symptoms and a short-term benefit on Sleep/fatigue,Mood/apathy,Attention/memory,Gastrointestinal,Urinary,Sexual function and Miscellaneous symptoms in PD patients.Moreover,it can reduce the medication intake and improve the patients' quality of life.

Key words: Parkinson's disease, Deep brain stimulation, Non-motor symptoms, Qualityoflife, Longitudinal study

中图分类号:

R742.5

王珏, 邱娴, 高颖, 寿文华, 徐露, 李殿友, 王林斌, 孙伯民, 朱大乔. 帕金森病患者双侧丘脑底核脑深部电刺激术后2年非运动症状的研究[J]. 立体定向和功能性神经外科杂志, 2023, 36(4): 193-199.

Wang Jue, Qiu Xian, Gao Ying, et al. A two-year survey on non-motor symptoms after bilateral subthalamic nucleus deep brain stimulation in patients with Parkinson's disease[J]. Chinese Journal of Stereotactic and Functional Neurosurgery, 2023, 36(4): 193-199.

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帕金森病患者双侧丘脑底核脑深部电刺激术后2年非运动症状的研究

A two-year survey on non-motor symptoms after bilateral subthalamic nucleus deep brain stimulation in patients with Parkinson's disease

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