基于倾向性匹配法分析颅内动脉瘤介入术后缺血并发症的危险因素

doi:10.19854/j.cnki.1008-2425.2023.03.0006

摘要/Abstract

摘要： 目的利用倾向性匹配法分析颅内动脉瘤介入术后缺血并发症的危险因素。方法回顾性分析本院2018年12月~2021年12月收治的245例颅内动脉瘤介入术患者的临床资料,其中术后缺血并发症54例。以1:1比例基于倾向性匹配法对混杂因素进行均衡处理,匹配后缺血并发症发生组和未发生组各52例。比较匹配前后缺血并发症发生与未发生患者的一般资料,对匹配后的数据进行Logistic回归分析探讨缺血并发症的危险因素。结果缺血并发症发生率为22.04%(54/245);年龄(OR=2.959,95%CI:2.009~3.910)、有吸烟史(OR=3.196,95%CI:2.095~4.298)、有饮酒史(OR=3.572,95%CI:2.252~4.891)、合并糖尿病(OR=3.873,95%CI:2.568~5.178)、合并高血压(OR=4.255,95%CI:3.041~5.468)、合并高脂血症(OR=4.802,95%CI:3.428~6.176)、动脉瘤直径(OR=6.848,95%CI:5.233~8.463)、术前动脉瘤破裂(OR=7.501,95%CI:6.066~8.935)、Hunt-Hess III~IV级(OR=9.043,95%CI:7.636~10.450)、合并血肿(OR=6.508,95%CI:4.928~8.088)均是缺血并发症的危险因素。结论颅内动脉瘤介入术后缺血并发症发生风险高,年龄、有吸烟史、有饮酒史、合并糖尿病、合并高血压、合并高脂血症、动脉瘤直径、术前动脉瘤破裂、Hunt-Hess III~IV级、合并血肿均是其危险因素。

关键词: 倾向性匹配, 颅内动脉瘤, 介入术, 缺血并发症

Abstract: Objective To analyze on the risk factors of ischemic complications after intracranial aneurysm interventional therapy by propensity matching method.Methods The clinical data of 245 patients with intracranial aneurysms who were treated in our hospital from December 2018 to December 2021 were analyzed retrospectively,including 54 patients with ischemic complications after operation.The mixed factors were balanced with 1:1 ratio based on tendency matching method.There were 52 cases in the ischemic complication group and 52 cases in the non ischemic complication group after matching.The general data of patients with and without ischemic complications were compared before and after matching.Logistic regression analysis was carried out on the matched data to explore the risk factors of ischemic complications.Results The incidence of ischemic complications was 22.04% (54/245).Age (OR=2.959,95% CI:2.009~3.910),smoking history (OR=3.196,95% CI:2.095~4.298),drinking history (OR=3.572,95% CI:2.252~4.891),diabetes (OR=3.873,95% CI:2.568~5.178),hypertension (OR=4.255,95% CI:3.041~5.468),hyperlipidemia (OR=4.802,95% CI:3.428~6.176),aneurysm diameter (OR=6.848,95% CI:5.233~8.463),preoperative aneurysm rupture (OR=7.501,95% CI:6.066~8.935),Hunt Hess Grade III~IV (OR=9.043,95% CI:7.636~10.450),and hematoma (OR=6.508,95% CI:4.928~8.088) were all risk factors for ischemic complications.Conclusion The risk of ischemic complications after intracranial aneurysm intervention is high.Age,smoking history,drinking history,diabetes,hypertension,hyperlipidemia,aneurysm diameter,aneurysm rupture before surgery,Hunt Hess III~IV,and hematoma are all risk factors.

Key words: Tendency matching, Intracranial aneurysm, Intervention, Ischemic complications

中图分类号:

R730.5

赵军, 马云云, 方洪伟, 范贝贝, 王钟玄, 陆青春, 吴胜波. 基于倾向性匹配法分析颅内动脉瘤介入术后缺血并发症的危险因素[J]. 立体定向和功能性神经外科杂志, 2023, 36(3): 157-163.

Zhao Jun, Ma Yunyun, Fang Hongwei, et al. Analysis of risk factors of ischemic complications after intracranial aneurysm intervention based on propensity matching method[J]. Chinese Journal of Stereotactic and Functional Neurosurgery, 2023, 36(3): 157-163.

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