帕金森病情感障碍的多模态识别研究进展与闭环调控展望

doi:10.19854/j.cnki.1008-2425.2025.05.0010

摘要/Abstract

摘要： 帕金森病(PD)除典型运动症状外,常伴有抑郁、焦虑等情感障碍,严重影响患者生活质量、治疗依从性及神经外科干预效果。临床识别面临困境:情感症状非典型、与运动症状交织,现有评估手段敏感性与特异性不足。其病理机制涉及情绪调控环路的结构与功能异常。近年来,多模态生物标志物为客观识别提供新途径:EEG可捕捉毫秒级情绪动态,fMRI揭示网络连接异常,眼动指标提供无创行为学补充。基于机器学习的多模态融合策略整合电生理、影像及行为数据,提升识别准确性与泛化能力,未来嵌入闭环神经调控系统,有望实现情绪状态驱动的个体化干预。本文综述PD情感障碍的识别困境与机制,探讨多模态方法在精准调控中的转化前景。

关键词: 帕金森病, 抑郁症, 焦虑症, 多模态生物标志物, 闭环脑深部电刺激

中图分类号:

742.5

张雨杨, 张宇清. 帕金森病情感障碍的多模态识别研究进展与闭环调控展望[J]. 立体定向和功能性神经外科杂志, 2025, 38(5): 315-320.

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