rs-fMRI对重复经颅磁刺激治疗后的酒精使用障碍患者冲动行为脑网络改变

doi:10.19854/j.cnki.1008-2425.2025.04.0003

立体定向和功能性神经外科杂志 ›› 2025, Vol. 38 ›› Issue (4): 204-212.DOI: 10.19854/j.cnki.1008-2425.2025.04.0003

rs-fMRI对重复经颅磁刺激治疗后的酒精使用障碍患者冲动行为脑网络改变

司延栋, 姚晓英, 牛亚辉, 余金鸣, 邢志强

528451 中山中山市第三人民医院医学影像科(司延栋,姚晓英,牛亚辉)、成瘾医学科(余金鸣)、心理保健科(邢志强)

收稿日期:2025-05-13 出版日期:2025-08-25 发布日期:2026-02-25
通讯作者: 邢志强 SIYAN198004dong0@yeah.vin
基金资助:
中山市科技局社会公益与基础研究项目(编号:2024B1086)

Rs-fMRI study on brain network changes in impulsive behavior of alcohol use disorder patients after repeated transcranial magnetic stimulation therapy

Si Yandong¹, Yao Xiaoying¹, Niu Yahui¹, Yu Jinming², Xing Zhiqiang³

1. Department of Medical Imaging,Zhongshan Third People's Hospital,Zhongshan,Guangdong,528451;
2. Department of Addiction Medicine,Zhongshan Third People's Hospital,Zhongshan,Guangdong,528451;
3. Department of Mental Health Care,Zhongshan Third People's Hospital,Zhongshan,Guangdong,528451

Received:2025-05-13 Online:2025-08-25 Published:2026-02-25
Contact: Xing Zhiqiang SIYAN198004dong0@yeah.vin

摘要/Abstract

摘要： 目的基于静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗前后的酒精使用障碍(alcohol use disorder,AUD)患者冲动行为脑网络改变。方法选取2022年12月至2024年12月于我院就诊的AUD患者为AUD组,同时选取同期在我院进行体检的健康者为对照组,每组初始计划纳入61例。根据纳排标准,AUD组和对照组分别排除15例,最终两组各纳入46例。通过SPSS23.0软件进行数据分析。运用双重差分(DID)模型评估效果。结果两组患者BIS-Ⅱ总评分和RBANS总评分均比干预前有明显下降(P＜0.05)。State1状态下,AUD组DMN和ECN间功能连接以增强为主;state2状态下,DMN和ECN间功能连接以减弱为主。AUD组state2状态平均持续时间与冲动行为评分呈负相关、与认知功能评分呈正相关(P＜0.05)。结论 rs-fMRI发现,rTMS治疗后的AUD患者,其冲动行为相关脑区中DMN和ECN的动态功能连接模式发生改变,该连接可反映大脑活动的瞬时变化,为AUD画着精准诊疗提供临床依据。

关键词: rs-fMRI, 重复经颅磁刺激, 酒精使用障碍患者, 脑网络

Abstract: Objective Exploring the changes in impulsive behavior brain networks in alcohol use disorder (AUD) patients before and after repeated transcranial magnetic stimulation (rTMS) treatment based on resting state functional magnetic resonance imaging (rs-fMRI). Methods Select AUD patients who visited our hospital from December 2022 to December 2024 as the AUD group,and select healthy individuals who underwent physical examinations at our hospital during the same period as the control group.The initial plan for each group is to include 61 cases.According to the inclusion and exclusion criteria,15 cases were excluded from the AUD group and the control group,and 46 cases were ultimately included in each group.Perform data analysis using SPSS23.0 software.Use the difference in differences (DID) model to evaluate the effectiveness. Results Both groups of patients showed a significant decrease in BIS-II total score and RBANS total score compared to before intervention (P＜0.05).In State 1 state,the functional connectivity between the AUD group DMN and ECN is mainly enhanced;In state2 state,the functional connection between DMN and ECN is mainly weakened.The average duration of state2 state in the AUD group was negatively correlated with impulsive behavior scores and positively correlated with cognitive function scores (P＜0.05). Conclusion rs-fMRI revealed that in AUD patients treated with rTMS,the dynamic functional connectivity patterns of DMN and ECN in the brain regions associated with impulsive behavior were altered,which can reflect transient changes in brain activity,provide clinical evidence for precise diagnosis and treatment of AUD.

Key words: rs fMRI, Repetitive transcranial magnetic stimulation, Patients with alcohol use disorders, Brain network

中图分类号:

R746.6⁺2

司延栋, 姚晓英, 牛亚辉, 余金鸣, 邢志强. rs-fMRI对重复经颅磁刺激治疗后的酒精使用障碍患者冲动行为脑网络改变[J]. 立体定向和功能性神经外科杂志, 2025, 38(4): 204-212.

Si Yandong, Yao Xiaoying, Niu Yahui, Yu Jinming, Xing Zhiqiang. Rs-fMRI study on brain network changes in impulsive behavior of alcohol use disorder patients after repeated transcranial magnetic stimulation therapy[J]. Chinese Journal of Stereotactic and Functional Neurosurgery, 2025, 38(4): 204-212.

参考文献

[1] Kranzler HR.Overview of alcohol use disorder[J].Am J Psychiatry,2023,180(8):565~572.
[2] Soyka M,Rösner S.Modern pharmacotherapy guidance for treating alcohol use disorders[J].Expert Opin Pharmacother,2025,26(2):147~156.
[3] Zhang FY,Li YL,Liu L,et al.Corticostriatal causality analysis in children and adolescents with attention-deficit/hyperactivity disorder[J].Psychiatry Clin Neurosci,2024,78(5):291~299.
[4] Forlim CG,Ascone L,Koch C,et al.Resting state network changes induced by experimental inaudible infrasound exposure and associations with self-reported noise sensitivity and annoyance[J].Sci Rep,2024,14(1):24555.
[5] Buetefisch CM,Wei L,Gu XH,et al.Neuroprotection of low-frequency repetitive transcranial magnetic stimulation after ischemic stroke in rats[J].Ann Neurol,2023,93(2):336~347.
[6] Yang Z,Qiao LR,He JH,et al.Effects of repetitive transcranial magnetic stimulation combined with functional electrical stimulation on hand function of stroke:a randomized controlled trial[J].NeuroRehabilitation,2022,51(2):283~289.
[7] Kajimura S,Margulies D,Smallwood J.Frequency-specific brain network architecture in resting-state fMRI[J].Sci Rep,2023,13(1):24555.
[8] 王力,高勇,胡晓璐,等.G-CSF介导的小胶质细胞自噬活性降低在大鼠酒精使用障碍脑卒中中的脑保护作用研究[J].临床和实验医学杂志,2024,23(12):1233~1237.
[9] 罗涛,陈美英,欧阳飞云,等.简式Barmtt冲动量表中文版的信效度检验[J].中国临床心理学杂志,2020,28(6):1199~1280.
[10] 贾晓楠,曾莹莹,甘玉洁,等.基于静息态功能磁共振成像检查的首发未治疗青少年女性抑郁症患者大脑功能活动变化观察[J].山东医药,2024,64(27):26~30.
[11] Roberts SCM,Liu GD,Terplan M.Medications for alcohol use disorder among birthing people with an alcohol-related diagnosis[J].J Addict Med,2025,19(1):41~46.
[12] Carr T,Kilian C,Llamosas-falcón L,et al.The risk relationships between alcohol consumption,alcohol use disorder and alcohol use disorder mortality:a systematic review and meta-analysis[J].Addiction,2024,119(7):1174~1187.
[13] Sanz J,Hernández-Martínez T,Castillo-Burgos P,et al.Prevalence of increased alcohol use and alcohol use disorders in adult victims of terrorist attacks:a systematic and meta-analytic review[J].Am J Drug Alcohol Abuse,2023,49(6):705~722.
[14] Petit B,Soudry-faure A,Jeanjean L,et al.Efficacy of repetitive transcranial magnetic stimulation (rTMS) for reducing consumption in patients with alcohol use disorders (alcostim):study protocol for a randomized controlled trial[J].Trials,2022,23(1):33.
[15] Hu MT,Qin BL Li T,et al.Efficacy of rTMS for poststroke epilepsy and its effects on patients' cognitive function and depressive status[J].BMC Neurol,2024,24(1):25.
[16] 冯祖幸,武桥,伍力,等.高频重复经颅磁刺激对急性脱瘾后男性酒精使用障碍患者线索注意力的影响[J].中华行为医学与脑科学杂志,2022,31(2):122~127.
[17] van Grinsven EE,Cialdella F,Verhoeff JJC,et al.Different profiles of neurocognitive functioning in patients with brain metastases prior to brain radiotherapy[J].Psycho Oncol,2023,32(11):1752~1761.
[18] Li JL,Tan CL,Zhang L,et al.Neural functional network of early Parkinson's disease based on independent component analysis[J].Cereb Cortex,2023,33(22):11025~11035.
[19] Kesan A,Dey P,Khanra S,et al.Low dose baclofen and standard dose acamprosate had comparable changes in brain glutamate,brain gamma amino butyric acid (GABA) and craving among patients with alcohol dependence syndrome:a 1h-mrs based open label randomized study[J].Ind Psychiatry J,2025,34(1):25~31.
[20] Jenwitheesuk A,Pabalan N,Tapanadechopone P,et al.Association of brain-derived neurotrophic factor polymorphisms with alcohol use disorder:an updated meta-analysis of genetic association studies[J].Brain Behav,2025,15(3):e70359.
[21] Requena-Ocaña N,Araos P,Serrano-Castro PJ,et al.Plasma concentrations of neurofilament light chain protein and brain-derived neurotrophic factor as consistent biomarkers of cognitive impairment in alcohol use disorder[J].Int J Mol Sci,2023,24(2):1183.
[22] Qin LY,Vetreno RP,Crews FT.Nadph oxidase and endoplasmic reticulum stress is associated with neuronal degeneration in orbitofrontal cortex of individuals with alcohol use disorder[J].Addict Biol,2023,28(1):e13262.
[23] 戴西勇,高磊,余金鸣,等.酒精使用障碍患者大脑皮层折叠模式改变的研究[J].罕少疾病杂志,2021,28(3):24~39.
[24] Rodriguez GC,Russell MA,Claus ED.Systematic review on resting-state fMRI in people with AUD and people who binge drink[J].Mol Psychiatry,2025,30(2):752~762.
[25] Yang W,Singla R,Maheshwari O,et al.Alcohol use disorder:neurobiology and therapeutics[J].Biomedicines,2022,10(5):1192.
[26] Hornsby N,Seedat S,Westman E,et al.The use of magnetic resonance imaging techniques in assessing the effects of alcohol consumption and heavy drinking on the adolescent brain:a scoping review protocol[J].Brain Sci,2021,11(6):764.

rs-fMRI对重复经颅磁刺激治疗后的酒精使用障碍患者冲动行为脑网络改变

Rs-fMRI study on brain network changes in impulsive behavior of alcohol use disorder patients after repeated transcranial magnetic stimulation therapy

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