LITT在神经外科的临床应用现状

doi:10.19854/j.cnki.1008-2425.2025.03.0010

摘要/Abstract

摘要： 磁共振引导下激光间质热疗(Laser Interstitial Thermal Therapy,LITT)近年来作为一种微创、精准、可控的热消融技术,在神经外科领域得到快速发展与广泛应用。LITT在实时MRI引导下将冷却激光光纤精确送入病灶,利用热效应实现病变组织消融,适用于脑深部、重要功能区附近或传统手术风险高的颅内病变。大量研究表明,LITT在胶质瘤(尤其是复发性和深部GBM)、脑转移瘤、复发性脑膜瘤、放射性坏死以及难治性癫痫中的局部控制率与传统手术相当甚至更优,且术后恢复快、激素依赖性低,并发症少。随着相关多中心前瞻性随机对照研究的开展、人工智能辅助影像分析与术前计划的优化、机器人技术操作精度的提高,以及与放化疗等多模态治疗手段的有机结合,LITT将为神经外科疾病的精准治疗提供更优解决方案

关键词: 激光间质热疗(LITT), 立体定向神经外科, 脑部疾病, 疗效

中图分类号:

R741

王新外, 张金男, 高宇飞. LITT在神经外科的临床应用现状[J]. 立体定向和功能性神经外科杂志, 2025, 38(3): 189-192.

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