基于回顾性队列研究的脑深部电刺激术对帕金森病患者非运动症状及生活质量的影响分析

doi:10.19854/j.cnki.1008-2425.2025.03.0001

摘要/Abstract

摘要： 目的探讨脑深部电刺激术对帕金森病患者非运动症状及生活质量的治疗效果。方法回顾性选取2021年11月～2024年6月我院收治的413例帕金森病患者,依据治疗方案分为保守组(201例)和手术组(212例)。保守组采取常规药物治疗,手术组在常规药物基础上采取脑深部电刺激术治疗。通过比较治疗前后两组患者的非运动症状、生活质量以及丙二醛、尿酸等生化指标水平评估治疗效果。结果治疗后6个月,两组患者在抑郁焦虑、头晕跌倒、认知、睡眠疲劳等9个非运动症状维度均较治疗前下降,且手术组改善幅度明显优于保守组(P＜0.05);治疗后两组患者的PDQ-39评分以及MDA、UA水平均较治疗前下降,且手术组降低较保守组更为明显(P＜0.05)。结论采取脑深部电刺激术对帕金森病患者实施干预,可有效缓解患者非运动症状,降低氧化应激水平,提升生活质量,为帕金森病患者综合管理策略的优化提供了临床证据。

关键词: 脑深部电刺激术, 帕金森病, 非运动症状, 生活质量, 队列研究

Abstract: Objective To explore the therapeutic effect of deep brain stimulation on non-motor symptoms and quality of life in patients with Parkinson's disease.Methods A total of 413 patients with Parkinson's disease admitted to our hospital from November 2021 to June 2024 were retrospectively selected and divided into the conservative group (201 cases) and the surgical group (212 cases) based on the treatment plan.The conservative group received conventional drug treatment,while the surgical group received deep brain stimulation on the basis of conventional drugs.The treatment effects were evaluated by comparing the non-motor symptoms,quality of life,and levels of biochemical indicators such as malondialdehyde and uric acid before and after treatment in both groups.Results Six months after treatment,the scores of non-motor symptoms such as depression and anxiety,dizziness and falls,cognition,and sleep fatigue in both groups were lower than those before treatment,and the improvement in the surgical group was significantly better than that in the conservative group (P＜0.05).The PDQ-39 scores and the levels of MDA and UA in both groups were lower after treatment than before treatment,and the reduction in the surgical group was more significant than that in the conservative group (P＜0.05).Conclusion The implementation of deep brain stimulation intervention in patients with Parkinson's disease can effectively alleviate non-motor symptoms,reduce oxidative stress levels,and improve quality of life,providing clinical evidence for the optimization of comprehensive management strategies for Parkinson's disease patients.

Key words: Deep brain stimulation, Parkinson's disease, Non-motor symptoms, Quality of life, Cohort study

中图分类号:

R742.5

刘晓晨, 朱珊珊, 张菁, 张建斌, 赵思任, 田艳艳, 梁锶锶. 基于回顾性队列研究的脑深部电刺激术对帕金森病患者非运动症状及生活质量的影响分析[J]. 立体定向和功能性神经外科杂志, 2025, 38(3): 129-134.

Liu Xiaochen, Zhu Shanshan, Zhang Jing, Zhang Jianbin, Zhao Siren, Tian Yanyan, Liang Sisi. Analysis of the Impact of Deep Brain Stimulation on Non-motor Symptoms and Quality of Life in Patients with Parkinson's Disease Based on a Retrospective Cohort Study[J]. Chinese Journal of Stereotactic and Functional Neurosurgery, 2025, 38(3): 129-134.

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