神经调控对帕金森病认知功能的影响

doi:10.19854/j.cnki.1008-2425.2025.02.0010

摘要/Abstract

摘要： 帕金森病(Parkinson’s disease,PD)是一种常见的神经系统退行性疾病,以运动和非运动症状为主要临床表现。其中,认知功能障碍是PD患者中最常见的非运动症状之一,当前临床治疗仍以药物干预为主导。尽管神经调控技术(包括侵入性技术,如脑深部电刺激,和非侵入性技术,如经颅磁刺激)已广泛应用于改善PD的运动症状,但其对认知功能的影响仍存在争议,亟须多学科证据明确其临床适用性。本文系统综述不同神经调控方式(侵入性和非侵入性)对PD患者认知功能的作用机制、刺激靶点及疗效差异,揭示其潜在的治疗价值与局限性,旨在为优化PD及相关神经退行性疾病认知障碍的治疗策略提供新的理论依据与实践方向。

关键词: 神经调控, 帕金森病, 认知功能障碍, 脑深部电刺激, 经颅磁刺激

中图分类号:

R742.5

徐庆, 昝翔, 曹培立, 陈东燕, 郭建忠. 神经调控对帕金森病认知功能的影响[J]. 立体定向和功能性神经外科杂志, 2025, 38(2): 119-124.

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