基于体素的形态学分析在帕金森病相关灰质改变中应用研究进展

doi:10.19854/j.cnki.1008-2425.2024.01.00011

摘要/Abstract

摘要： 帕金森病(Parkinson'S disease,PD)是一种常见于中老年人的渐进性神经变性疾病。基于体素的形态学分析(voxel-based morphometry,VBM)可以在体素水平上定量检测出脑组织的密度和体积的改变,尤其是灰质(GM)的改变。由于PD患者的GM变化复杂且临床症状多样,许多学者对其从多个相关方向进行了VBM研究,特别是与临床症状相关GM改变的研究成为了现在研究的热点。但由于PD患者的复杂性和个体性差异,相关GM变化的VBM结果不尽相同,而且在与PD的核心致病机制相关的黑质-纹状体通路的研究还比较缺乏,不过多项研究结果表明VBM在研究PD相关的GM改变具有很大的潜力。

关键词: 帕金森病, 基于体素的形态学分析, 灰质, 诊疗

中图分类号:

R742.5

田川, 张新定, 王小强, 兰正波, 史雪峰, 杨宝慧, 李正斌. 基于体素的形态学分析在帕金森病相关灰质改变中应用研究进展[J]. 立体定向和功能性神经外科杂志, 2024, 37(1): 54-62.

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