关键词: 高级别脑胶质瘤, 异柠檬酸脱氢酶1, MRI, 基因突变

Abstract: Objective To study the correlation between isocitrate dehydrogenase-1 (IDH1) and post-treatment MRI features and itsprognosis value in high-grade gliomas.Methods Retrospectively analysis was performed on clinical,IDH gene type and postoperative MRI data from HGG patients who came toour hospital for treatment from January 2014 to January 2021.96 HGG patients were included with 61 were IDH wild-type and 35 mutant type.DTT map,fractional anisotropy (FA) map of DTI,cerebral blood flow (CBF) of ASL and apparent diffusion coefficient (ADC) of DWI were obtained after 6 month post-treatmentMRIimage processing on Siemens Syngo.via workstation coefficient.Results There were more patients with grade IV in IDH wild type.In the DWI sequence frame,mutant patients presented highernADCbut lowernCBF(P＜0.05).In SWI sequence,the number of IDH1 wild-type patients with ITSS3 grades was higher than that of IDH1-mutant glioma patients (P＞0.05).The follow-up time of patients was between 15~43 months,and the median follow-up time was 26 months.The median PFS of IDH1 wild-type HGG patients was 10 months,and the median PFS of IDH1 mutant HGG patients was 17 months (P＜0.05).The median OS of IDH1 wild-type HGG patientswas 13 months,and the median OS of IDH1 mutant HGG patients was 22.5 months(P＜0.05).The area under the ROC curve of IDH1 genotype for the prognosis of HGG patients was 0.585,the area under the ROC curve of the combination of nADC,nCBF,and ITSS grades for the prognosis of HGG patients was 0.874.While the ROC curve combined with IDH1 genotype,nADC,nCBF,ITSS grade and histopathological grade for the prognosis of HGG patients was 0.926.Conclusion There are differences in MRI characteristic parameters between IDH1 wild type and mutant HGG patients,and the combination of IDH1 genotype,MRI characteristic parameters and histopathological grade has positive significance for evaluating prognosis of HGG patients.

Key words: High-grade glioma, Isocitrate dehydrogenase 1, MRI, Gene mutation