关键词: 创伤性脑损伤, 弥漫性轴索损伤, 扩散峰度成像, 脑血流量, 空间关系

Abstract: Objective To evaluate the spatialcorrelationbetweendiffusion kurtosis imaging (DKI) andcerebralbloodflow (CBF) of diffusion-weighted magnetic resonance imaging (DW-MRI) in patients with traumatic brain injury (TBI).Methods 30 cases of patients with TBI (Research group) and 30 cases of matched healthy volunteers (Control group) were enrolled in the first hospital of Zhangjiakou city from January,2020 to December,2020.Axonalintegrityof DKI examination and CBF measured by arterial spin labeling (ASL) were performed 5 to 19 days enrolledin Research groups of patients after injury and Control patients.Mean values of mean kurtosis (MK),Kurtosis anisotropy (KA) and anisotropy fraction (FA),CBF were extracted for pre-determined regions of interest (ROIs).Normalized z-score maps were generated from the pool of healthy controls to compare the two groups and their spatial positioning relationship with CBF.Results whole brain,white matter volume of 30 patients of TBI were positively correlated with CBF (r=0.500,r=0.818,both P＜0.01).Further analysis showed that abnormal blood flow in TBI patients was mainly presented in the hippocampus,thalamus,amygdala and temporal gyrus,among which,the CBF of bilateral temporal gyrus decreased by 10% approximately compared with the Control groups.DKI parameters suggested that extensive DAIwere observed in the white matter of the brain in TBI patients,mostly in the foot of the cerebrum,corpus callosum,anterior and posterior limbs of the left and right capsule,pons and so on.Compared with two groups,the indexes of the Research group were significantly lower than those of the Control group (P＜0.05),in the ROIs area,about 3.83% of the abnormal KA area also had abnormal MK value.In the abnormal area of CBF,abnormal MK and KA accounted for 6.36% and 7.64%,respectively,and the abnormal FA region overlaps with CBF by 9.87%.Conclusion Change of DAI microstructure in brain tissue were showed from parameters of DKI,and there is limited correlation between DAI microstructure injury and cerebral vascular perfusion.

Key words: Traumatic brain injury, Diffuse axonal injury, Diffusion kurtosis imaging, Cerebral blood flow, Spatial relationship