关键词: 三叉神经体感诱发电位, 三叉神经通路, 偏头痛

Abstract: Objective To investigate the changes and significance of trigeminal somatosensory evoked potentials (TSEP) in patients with migraine without aura (MO) during interictal period.Methods 52 patients with migraine without aura diagnosed in the First Affiliated Hospital of University of Science and Technology of China from October 2020 to June 2022 were enrolled as MO group and 52 healthy cases were also included as healthy control group(HC).All subjects were examined by TSEP.The latency of each wave (N13,P19 and N30),peak interpeak period,peak-to-peak amplitude and sensory threshold were taken as the analytical indexes of TESP,and the differences of TSEP indexes between the two groups were compared.Furthermore,according to the course of disease and the degree of pain,the differences of TSEP indexes among MO subgroups were compared too.Results The latency of TSEP in MO group was significantly longer than that in HC group,and the difference was statistically significant (P＜0.001).Among the subgroups of the course of disease,the sensory threshold of TSEP decreased and the amplitudes of each wave increased with the prolongation of the course of disease.The difference in left sensory threshold,left N30/P19 amplitude and right N13/P19 amplitudewas statistically significant (P＜0.05).Between subgroups of pain degree,there was no significant difference in TSEP between the two groups (P＞0.05).Conclusion The TSEP indexes were abnormal in patients with migraine without aura.Migraine with longer duration may affect the reactivity and excitability of trigeminal pathway in cortex and brainstem.

Key words: Trigeminal somatosensory evoked potential, Trigeminal pathway, Migraine