右美托咪定在立体定向手术中的临床应用进展

doi:10.19854/j.cnki.1008-2425.2022.03.0013

摘要/Abstract

摘要： 右美托咪定(dexmedetomidine,DEX)作为一种高选择性的α2肾上腺素受体激动剂,在产生镇静作用的同时不抑制患者的呼吸,其镇静过程类似于自然睡眠,具有可唤醒性。立体定向手术大多需要框架系统辅助定位,手术涉及重要脑功能区,需要进行电生理功能监测及患者的配合。目前研究表明低剂量的DEX在产生有效镇静的同时不会干扰电生理监测,并且可以在需要的时候将其唤醒,适用于立体定向下的脑功能区手术及唤醒麻醉。文章围绕DEX的作用机制以及其在立体定向手术中的应用及优势展开综述,为优化立体定向手术的麻醉管理提供依据。

中图分类号:

R741

范泽峰, 康芳. 右美托咪定在立体定向手术中的临床应用进展[J]. 立体定向和功能性神经外科杂志, 2022, 35(3): 188-192.

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