立体定向和功能性神经外科杂志 ›› 2025, Vol. 38 ›› Issue (6): 321-326.DOI: 10.19854/j.cnki.1008-2425.2025.06.0001

• 论著 •    下一篇

射频热凝术、微血管减压术和经皮穿刺球囊压迫术治疗三叉神经痛的疗效对比

李波, 李小波, 谢东   

  1. 056004 邯郸市 河北省邯郸市第一医院介入血管外科(李波),河北医科大学第一医院心外科(李小波),保定市第一医院神经外科(谢东)
  • 收稿日期:2024-11-05 发布日期:2026-02-10
  • 通讯作者: 谢东 y2tt2f9g@163.com
  • 基金资助:
    河北省卫生健康委医学科学研究项目(编号:20241335)

Comparison of the efficacy of radiofrequency thermocoagulation,microvascular decompression and percutaneous balloon compression in treating trigeminal neuralgia

Li Bo1, Li Xiaobo2, Xie Dong3   

  1. 1. First Hospital of Handan City Interventional Vascular Surgery Handan City, Hebei Province 056004;
    2. First Hospital of Hebei Medical University Cardiac Surgery Shijiazhuang City, Hebei Province 2050031;
    3. First Hospital of Baoding City Neurosurgery Baoding City, Hebei Province 07100
  • Received:2024-11-05 Published:2026-02-10
  • Contact: Xie Dong y2tt2f9g@163.com

摘要: 目的 比较射频热凝术(RFT),微血管减压术(MVD)和经皮穿刺球囊压迫术(PBC)治疗三叉神经痛(PTN)的疗效。方法 选取保定市第一医院于2022年6月-2023年6月收治的120例PTN患者作为研究对象,随机分为A组(RFT)、B组(MVD)、C组(PBC),每组各40例,比较三组的临床疗效、血清炎性因子、神经递质、氧化应激反应、预后(不良反应与复发率)。结果 B组的总缓解率(97.50%)大于A组(77.50%)和C组(80.00%)(P<0.05);术后,B组的白细胞介素-1β(IL-1β)、IL-6、肿瘤坏死因子-α(TNF-α)、降钙素基因相关肽(CGRP)、P物质(SP)及丙二醛(MDA)水平均小于A、C组,5-羟色胺(5-HT)、β-内啡肽(β-EP)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)高于A、C组(P<0.05);B组的不良反应发生率及复发率均小于A、C组(P<0.05)。结论 MVD治疗PTN的疗效更佳,能够显著降低炎症反应,改善神经递质水平和氧化应激反应,且预后情况较好。

关键词: 射频热凝术, 微血管减压术, 经皮穿刺球囊压迫术, 三叉神经痛

Abstract: Objective To compare the efficacy of radiofrequency thermocoagulation(RFT),microvascular decompression(MVD),and percutaneous balloon compression(PBC) in treating trigeminal neuralgia(PTN). Methods From June 2022 to June 2023,120 patients with PTN admitted to Baoding First Hospital were regarded as the study subjects and grouped into group A(RFT),group B(MVD),and group C(PBC) randomly,with 40 patients in each group.The efficacy,serum inflammatory factors,neurotransmitters,oxidative stress response,and prognosis(adverse reactions and recurrence rate) of the three groups were compared. Results The overall response rate of group B(97.50%) was higher than that of group A(77.50%) and group C(80.00%)(P<0.05).After surgery,the levels of interleukin-1β(IL-1β),IL-6,tumor necrosis factor-α(TNF-α),calcitonin gene-related peptide(CGRP),substance P(SP),and malondialdehyde(MDA) in group B were lower than those in groups A and C,however,the levels of 5-hydroxytryptamine(5-HT),β-endorphin(β-EP),superoxide dismutase(SOD),and glutathione peroxidase(GSH-Px) were higher in groups A and C(P<0.05).The incidence of adverse reactions and recurrence rate in group B were lower than those in groups A and C(P<0.05). Conclusion MVD has a better healing effect on PTN.It can prominently reduce inflammatory response,improve neurotransmitter levels and oxidative stress response,and has a good prognosis.

Key words: Radiofrequency thermocoagulation, Microvascular decompression, Percutaneous balloon compression, Primary trigeminal neuralgia

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