关键词: 后颅窝肿瘤, 儿童, 颅内感染, 危险因素

Abstract: Objective To investigate the risk factors of cerebrospinal fluid infection in children with posterior fossa tumors after operation.Methods 96 children with posterior fossa tumors in our hospital from October 2020 to October 2024 were selected in the Department of Neurosurgery,The Affiliated Children's Hospital of Xi'an Jiaotong University and divided into infection group (18 cases) and non infection group (78 cases) according to whether intracranial infection occurred after operation.The clinical data of the two groups were compared,and the risk factors of intracranial infection were analyzed by multivariate logistic regression.Results The incidence of intracranial infection was 18.75% in the 96 cases of children.Univariate analysis showed that there was no significant differece in gender,age,weight,preoperative albumin(P＞0.05).Univariate analysis showed that there had significant difference in tumor volumes,operation time,external ventricular drainage,blood loss and postoperative cerebrospinal fluid leakage(P＞0.05).Multivariate Logistic regression analysis showed that tumor volumes,operation time,external ventricular drainage,blood loss and postoperative cerebrospinal fluid leakage were risk factors of intracranial infection.After lumbar puncture and antibiotic treatment,intracranial infection was cured.The course of treatment was about 2 to 6 weeks.Conclusion The occurrence of postoperative intracranial infection in children with posterior fossa tumors were affected by many factors,among which tumor volumes,operation time,operation blood loss,external ventricular drainage and cerebrospinal fluid leakage were risk factors of postoperative infection.Clinicians should pay more attention to avoid intracranial infection.

Key words: Posterior fossa tumor, Children, Intracranial infection, Risk factors