关键词: 高频重复经颅磁刺激, 抑郁症, 疗效, 影响因素

Abstract: Objective To analyze the efficacy and influencing factors of high-frequency repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression.Methods The clinical data of 80 patients with depression who were given drug therapy combined with high-frequency rTMS admitted to the Affiliated Hospital of Wanxi Health Vocational College were retrospectively analyzed between May 2019 and May 2022,and the patients were classified as the study group.Another 80 patients with depression who only adopted drug therapy during the same period were used for controls,and they were set as the control group.Hamilton Depression Scale (HAMD) was used to evaluate the depressive symptoms of patients after treatment,and the treatment effect was compared.The patients in the study group were divided into effective treatment group (n=51) and ineffective treatment group (n=29) according to the changes in HAMD score after treatment.Univariate comparison was performed on clinical data such as gender,age,education level,family history of mental illness,disease course,sleep status,exercise status,treatment compliance,quality of life,family intimacy,cognitive ability and combined physical diseases,and unconditional Logistic multivariate stepwise regression analysis was performed on indicators with significant differences to analyze the influencing factors affecting the efficacy of high-frequency rTMS in the treatment of patients with depression.Results The effective rate of drug therapy combined with high-frequency rTMS treatment was 63.75%,and the efficacy of the study group was significantly higher than that of the control group (P＜0.05).Sleep status,treatment compliance,family intimacy and cognitive ability were all independent factors that affected the efficacy of high-frequency rTMS in the treatment of depression (all P＜0.05).Conclusion Drug therapy combined with high-frequency rTMS has a high efficacy in the treatment of depression,and the sleep status,treatment compliance,family intimacy and cognitive ability during treatment are the influencing factors of its efficacy.In clinical practice,corresponding intervention measures can be implemented according to the influencing factors so as to improve the prognosis of patients.

Key words: High-frequency repetitive transcranial magnetic stimulation, Depression, Efficacy, Influencing factors