关键词: 脑深部电刺激术, 中晚期帕金森病, 生活质量

Abstract: Objective To explore the effect of deep brain stimulation on quality of life in patients with medium-late stage Parkinson's disease.Methods There were 82 males and 85 females in this group.Their ages ranged from 41 to 77 years(mean 62.55 years).Their illness duration ranged from 3 to 22 years(mean 5.52 years).The clinical classification showed tremor-type in 35 cases,rigidity-type in 59 cases and tremor-rigidity-mixed-type in 73 cases.All the 167 cases were divided into three different groups according to different treatment methods:DBS group,lesioning group and medical treatment alone group.Activity of Daily Living(ADL) Scale and Parkinson's Disease Questionnaire (PDQ-39) were used to evaluate the patient's quality of life(QOL) before the therapy and 12 months after the therapy respectively.Results Bilateral STN-DBS was performed in 22 cases,deep nuclus lesioning was performed in 74 cases(including Gpi in 8 cases and Vim in 66 cases),and 71 cases received medical treatment alone.There was significant difference(P<0.05)in UPDRS of both surgical groups between 1 week before-operation and 1 year after-operation.12 months after the operation the ADL scores of both surgical groups were significantly higher than those before treatment(P＜0.05),and PDQ-39 scores were significantly lower than those before treatment(P＜0.05).Meanwhile the ADL scores of both surgical groups were significantly higher than those of medical treatment alone group(P＜0.05),and PDQ-39 scores were significantly lower than those of medical treatment alone group(P＜0.05).The ADL scores of DBS group were significantly higher than those of lesioning group(P＜0.05),and PDQ-39 scores of DBS were significantly lower than those of lesioning group(P＜0.05).Conclusion DBS not only can improve the motor symptoms of PD significantly,but also can ameliorate the non-motor symptoms (NMS),which can greatly improve the quality of life in patients with medium-late stage Parkinson's disease.

Key words: Deep brain stimulation, Medium-late stage PD, Quality of life