关键词: 加速康复外科, 唤醒麻醉技术, 脑胶质瘤, 肿瘤切除程度, 语言功能, 运动功能

Abstract: Objective To investigate the application of intraoperative wake-up anesthesia technique based on accelerated rehabilitation surgery (ERAS) in patients with glioma and its effects on the extent of tumor resection,postoperative language and motor function.Methods 159 patients with glioma in our hospital from January 2020 to January 2022 were selected and grouped differently according to the order of admission and establishment,with the observation group adopting intraoperative arousal anesthesia technique based on ERAS,the control A group adopting intraoperative arousal anesthesia technique,and the control B group receiving conventional anesthesia management.The surgery-related indexes,degree of tumor resection and pre- and post-operative speech function,motor function,quality of life and postoperative complications were compared among the three groups.Results When comparing the bleeding volume and operation time of the three groups,there was no significant difference (P＞0.05);the ICU supervision and postoperative hospitalization time of the observation group were shorter than those of the control A and B groups (P＜0.05);when comparing the degree of tumor resection of the three groups,the difference was not statistically significant (P＞0.05);the VFT,BNT,and ABC scores of the observation group were higher than those of the control A and B groups,and those of the control A group were higher than those of the control B group 1 month after surgery (P<0.05);Fugl-Meye and ADL scores were higher in the observation group than in control groups A and B,and higher in control group A than in control group B at 1 month after surgery (P<0.05);EORTCQLQ-C30 scores were higher in the observation group than in control groups A and B,and higher in control group A than in control group B at 1 month after surgery (P<0.05).Complication rates in the three groups were not statistically significant compared with each other (P>0.05).Conclusion In ERAS-based arousal anesthesia technique applied to patients with glioma can promote early postoperative recovery,improve language and motor function,and enhance the level of survival quality.

Key words: Accelerated rehabilitation surgery, Arousal anesthesia technique, Glioma, Degree of tumor resection, Language function, Motor function