磁共振灌注加权成像联合NODDI技术对脑胶质瘤分级诊断的临床价值分析

doi:10.19854/j.cnki.1008-2425.2022.03.0004

立体定向和功能性神经外科杂志 ›› 2022, Vol. 35 ›› Issue (3): 142-146.DOI: 10.19854/j.cnki.1008-2425.2022.03.0004

磁共振灌注加权成像联合NODDI技术对脑胶质瘤分级诊断的临床价值分析

陈欢, 郝璐, 王禄伟, 马景旭, 刘莹, 姜磊, 王红

830028 乌鲁木齐新疆医科大学第二附属医院医学影像科

收稿日期:2022-04-15 出版日期:2022-06-25 发布日期:2022-09-14
基金资助:
新疆维吾尔自治区卫建委青年医学科技人才专项项目(编号:WJWY-202209)

Clinical value of perfusion weighted magnetic resonance imaging combined with noddi in grading diagnosis of glioma

Chen Huan, Hao Lu, Wang Luwei, et al

Department of medical imaging,the Second Affiliated Hospital of Xinjiang Medical University,Urumqi,830028,China

Received:2022-04-15 Online:2022-06-25 Published:2022-09-14

摘要/Abstract

摘要： 目的探讨磁共振灌注加权成像(DSC-PWI)联合神经突定向扩散与密度成像(NODDI)技术对脑胶质瘤分级诊断的临床价值。方法选择我院从2020年3月～2022年3月收治的74例脑胶质瘤患者为观察对象。所有患者均实施DSC-PWI以及NODDI检查,比较不同级别脑胶质瘤患者病灶实质区各项DSC-PWI以及NODDI参数的差异。以病理检查结果为金标准,分析DSC-PWI联合NODDI及两者单独诊断脑胶质瘤分级的效能。结果低级别组病灶实质区DSC-PWI参数中的rCBV、rCBF及MTT分别为(1.35±0.24)、(1.35±0.24)、(1.02±0.31),均低于高级别组的(4.71±1.03)、(4.24±1.21)、(1.24±0.32)(均P＜0.05)。低级别组病灶实质区NODDI参数中的ICVF、ODI及VISO分别为(0.25±0.02)、(0.29±0.03)、(0.16±0.01),均低于高级别组的(0.39±0.04)、(0.35±0.05)、(0.22±0.03)(均P＜0.05)。以病理检查结果为金标准,DSC-PWI联合NODDI诊断脑胶质瘤分级的灵敏度、特异度以及准确度分别为96.97%、97.56%、97.30%,均高于DSC-PWI单独诊断的75.76%、78.05%、77.03%以及NODDI单独诊断的78.79%、82.93%、81.08%(均P＜0.05)。结论 DSC-PWI联合NODDI对脑胶质瘤分级诊断的价值较高。

关键词: 脑胶质瘤, 分级诊断, 磁共振灌注加权成像, 神经突定向扩散与密度成像

Abstract: Objective To investigate the clinical value of magnetic resonance perfusion weighted imaging (dsc-pwi) combined with neurite directed diffusion and density imaging (noddi) in the grading diagnosis of glioma.Methods 74 patients with glioma treated in our hospital from March 2020 to March 2022 were selected as the observation objects.All patients underwent DSC-PWI and NODDI.To compare the differences of DSC-PWI and NODDI parameters in the focus parenchyma of patients with different grades of glioma.Using pathological examination results as the gold standard,the efficacy of DSC-PWI combined with NODDI and the two alone in diagnosing glioma grade was analyzed.Results RCBV,rCBF and MTT in DSC-PWI parameters of parentologic lesions in low-grade group were (1.35±0.24),(1.35±0.24),(1.02±0.31),respectively.Lower than those in advanced group (4.71±1.03),(4.24±1.21),(1.24±0.32) (P<0.05).The ICVF,ODI and VISO in NODDI parameters of parenchymal lesions in low-grade group were (0.25±0.02),(0.29±0.03),(0.16±0.01) respectively.All of them were lower than those in high grade group (0.39±0.04),(0.35±0.05),(0.22±0.03) (P<0.05).Using pathological examination results as the gold standard,the sensitivity,specificity and accuracy of DSC-PWI combined with NODDI in diagnosing glioma grade were 96.97%,97.56% and 97.30% respectively,which was higher than 75.76%,78.05%,77.03% of DSC-PWI alone and 78.79%,82.93%,81.08% of NODDI alone (all P<0.05).Conclusion DSC-PWI combined with NODDI has a high value in grade diagnosis of glioma.

Key words: Glioma, Hierarchical diagnosis, Magnetic resonance perfusion weighted imaging, Directional diffusion and density imaging of neurite

中图分类号:

R739.41

陈欢, 郝璐, 王禄伟, 马景旭, 刘莹, 姜磊, 王红. 磁共振灌注加权成像联合NODDI技术对脑胶质瘤分级诊断的临床价值分析[J]. 立体定向和功能性神经外科杂志, 2022, 35(3): 142-146.

Chen Huan, Hao Lu, Wang Luwei, et al. Clinical value of perfusion weighted magnetic resonance imaging combined with noddi in grading diagnosis of glioma[J]. Chinese Journal of Stereotactic and Functional Neurosurgery, 2022, 35(3): 142-146.

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磁共振灌注加权成像联合NODDI技术对脑胶质瘤分级诊断的临床价值分析

Clinical value of perfusion weighted magnetic resonance imaging combined with noddi in grading diagnosis of glioma

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